Pharmacy & Pharmacology International Journal最新文献

{"title":"Pilot study to compare the use of the national program drugs ALONE versus their combination with Artemisia Afra infusions for the treatment of pulmonary tuberculosis","authors":"Pascal Gisenya, Patrick E Ogwang, Elkan Katotola, Adele Ntezahorigwa, Claudette Ndayininahaze","doi":"10.15406/ppij.2023.11.00410","DOIUrl":"https://doi.org/10.15406/ppij.2023.11.00410","url":null,"abstract":"","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135938147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in MS related pain, correlation with MRI lesion localization and burden of disease","authors":"M. Avila, V. Neugebauer, J. DeToledo","doi":"10.15406/ppij.2021.09.00354","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00354","url":null,"abstract":"Multiple Sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS). It is the most common cause of acquired neurologic dysfunction in young patients. It is an autoimmune condition and is more prevalent in woman.1 The incidence of MS in the United States is approximately 85-100 cases per 100,000 people per year. The ratio of women to men has been estimated to be 2.6:1.1 The evaluation and diagnosis of MS is critically dependent on the findings of Magnetic Resonance Imaging (MRI). Characteristically MS plaques are multiple, hyperintense in T2 weighted images and Fluid Attenuated Inversion Recovery (FLAIR). Hypointense lesions in T1-WI are associated with areas of myelin loss.2 Brain MRI is important in treatment decisions as lesions may be clinically silent.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75934702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of silodosin-a review of literature","authors":"Gokhan Faikoglu, Kubra Saygisever-Faikoglu, Fatmanur Otmar Ozcan, B. Berk","doi":"10.15406/ppij.2021.09.00353","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00353","url":null,"abstract":"clinical global ejaculation latency times; IPSS, international prostate symptom score; lower urinary tract lower urinary benign MCC, maximum cystometric capacity; postvoid residual urine volume; Rej, retrograde ejaculation; transurethral incision of the prostate; Background: Benign prostatic hyperplasia is a compilation of irritative voiding and obstructive symptoms which are consistent with reduced emptying of urine from and defective storage of urine in the bladder. Medications are a common method of treatment to delay complications and reduce symptoms. Silodosin is a highly selective alpha-1A adrenoceptor blocker that has 162 times more affinity for alpha-1a than alpha 1b, thus resulting in high uroselectivity and decreased side effects. Aim: In this review article our aim was to elucidate the clinical effects, safety and tolerability profile of silodosin in the treatment of benign prostatic hyperplasia. Method: Literatures were retrieved by a PubMed search, using different combinations of pertinent keywords (e.g., silodosin, hypotension, benign prostatic hyperplasia), without any limitations in terms of publication date and language. Papers which assessed the therapeutic efficacy and tolerability of silodosin were selected for inclusion according to their relevance for the topic, as judged by the authors. Overvıew of clinical data: Silodosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia. It has a rapid onset of effect in men with lower urinary tract symptoms and improvements were seen in voiding and storage symptoms, maximum urinary flow rate and health-related quality of life. The efficacy of silodosin was maintained in several controlled studies and also non-interventional real-world setting. Silodosin was generally well tolerated. Conclusion: Silodosin is the most uroselective α-blocker. Silodosin has been emphasized in the 2021 European Association of Urology Conservative treatment of non-neurogenic male LUTS guidelines and it has been reported that the hypotensive effect of silodosin is comparable with placebo and has favorable safety and tolerability profile. Dosing of silodosin does not need to be adjusted according to age, concurrent medication with antihypertensives and phosphodiesterase type 5 inhibitors.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74641030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribenoside–lidocaine combination in wound healing of hemorrhoids: a review of literature","authors":"Gokhan Faikoglu, Kubra Saygisever-Faikoglu, F. Ozcan","doi":"10.15406/ppij.2021.09.00351","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00351","url":null,"abstract":"Background: Hemorrhoids are one of the most common anorectal disease observed in clinical practice. Symptomatic hemorrhoids can be effectively treated with a pharmacological approach, particularly with topical drugs, associated with dietary and lifestyle changes. this review is to assess the effectiveness of tribenoside 5% + lidocaine 2% combination cream and suppository forms to manage the acute symptomatology of patients with hemorrhoids. Method: Literatures were re trieved by a PubMed search, using different com binations of pertinent keywords (e.g., wound healing, tribeno side, hemorrhoids), without any limitations in terms of publication date and language. Papers which assessed the therapeutic efficacy and tolerability of tribenoside + lidocaine combination in patients with hemorrhoids were se lected for inclusion according to their relevance for the topic, as judged by the authors. Results: Five studies compared tribenoside + lidocaine combination with each of its single components: in 3 studies tribenoside + lidocaine was compared with lidocaine and in 2 studies with tribenoside. Moreover in 6 studies tribenoside + lidocaine has been compared with a corticosteroid containing preparation and 2 studies evaluated the product effectiveness in women with hemorrhoids, as a consequence of pregnancy or delivery. The results of all studies showed that the association tribenoside + lidocaine was significantly superior to lidocaine alone and had a similar clinical efficacy compared to tribenoside and corticosteroids. However, the tribenoside + lidocaine showed a faster relief of subjective symptomatology, than tribenoside and corticosteroids, with the advantage to avoid the possible steroid-related side-effects. Tribenoside + lidocaine has been well tolerated. Conclusion: In conclusion, tribenoside + lidocaine represents a rapid, effective and safe option for treatment of hemorrhoids, and should be recommended as first-line treatment of this disease in clinical practice for its long-lasting healing effects on hemorrhoids with high efficacy and good tolerability. first study was a randomized double-blind study comparing tribenoside+lidocaine cream (n=14) with lidocaine 2% cream (n=14) . The 2nd and 3th were open-label investigations with tribenoside+lidocaine cream (n=60) and suppositories (n=44) The 4th study compared preparations (hydrocortisone triamcinolone prednisolone (n=45)). times daily for 10 days (post-partum) or 20 days (pregnancy). Results were rated as excellent in 15, good in 18 and minimal in 7 patients (globally good or very good results in 82.5% of subjects) . Tolerability was favorable in all cases and no systemic or local adverse effects have been observed. 19","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91344224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectively of favipiravir as antiviral therapy in the treatment of covid-19 in the several hospital in Blora, Indonesia","authors":"Metrikana Novembrina, Ayu Anggara Ati","doi":"10.15406/ppij.2021.09.00349","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00349","url":null,"abstract":"The outbreak of Corona virus Disease 2019 (COVID-19) in December 2019 in China, has become a pandemic in March 2020. A clinical study in China on the effectiveness of favipiravir involving 320 COVID-19 patients stated that favipiravir was safe and efficacious in the treatment of COVID-19. However, in Indonesia, the clinical studies on the effectiveness and the toxicity of the antiviral are so lacking that the further research will be needed. The objective of the study is to analize the effectiveness of favipiravir as an antiviral therapy in the treatment of COVID-19 in several hospital in the district of Blora, Central Java, Indonesia. In this study as many as 266 samples of the patient’s medical record which met the inclusion criteria were devided into group 1 which given favipiravir and group 2 which not given favipirafir. Data were then analized by using chi-square with continuity correction to evaluate the difference in proportion of those who were given the antiviral and those who were not, in relation to the outcome. The result showed that as many as 92.5% of the patient given favipiravir showed an improved outcome and 7.5% of those were reported dead. As many as 80.5% of those not given favipiravir showed an improved outcome and 19.5% of those were reported dead. Based on the chi square with continuity correction, it revealed that there was significant difference in the proportion among the groups in relation to the outcome (p<0,05). Based on the results and discussions, it is concluded that favipiravir is effective to be used as an antiviral drug in the treatment of COVID-19.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"53 76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88568988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell death induction of dibutyl phthalate (DBP) on primary brain cells from adult zebrafish","authors":"B. Zayas, Gloria Carrasquillo, Naysha Pinet-Velez, C. Vélez, J. Ortiz","doi":"10.15406/ppij.2021.09.00348","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00348","url":null,"abstract":"The presence of phthalates as plasticizer on pharmaceutical products as well as in aquatic environments requires serious attention. Phthalates are compounds widely used in the manufacturing industry and has been associate with multiple adverse health effects to human. Among the family of phthalates Dibutyl phthalate (DBP) is well used for pharmaceutical products. Limited information however has been generated on the effect of DBP on the brain. The objective of this investigation was to characterize potential neurotoxicity resulting from short term exposure to DBP. Considering the efficacy and sensitivity of the zebrafish model as an early stage- screening tool, and their neurological and biochemical similarities to those of human, this study evaluates the effect of DBP on primary brain cells of the adult zebrafish. This well optimized and implemented methodology can be consider a guide for future studies using primary cells of adult zebrafish given the reduction on reagents, and the number of cells used for treatment. For indirect confirmation of extracted nervous tissue, the Acetylcholinesterase activity (AChEs) assay kit was implemented. In our study primary cells from adult zebrafish brain were exposed to DBP for 24 hours at aerobic environment at concentrations from 3uM to 100μM. The effect on cell viability as well as cell death mechanisms was determined. Results indicate that adult primary brain cells viability is compromised as low as 8uM of DBP. In terms of mechanism, cells undergo apoptosis and autophagy at concentrations of 8μM and 100μM. This study confirms that low concentrations of DBP over a 24-hour period induces apoptosis and autophagy, potentially activating degradation of brain cells and altering biochemical processes of the nervous system. This research presents a novel approach for future molecular studies using brain primary cells as model to screen pharmaceuticals and environmental agents for risk assessment.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"30 11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78629001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dried ginger water extract on hypertriglyceridemia induced acute pancreatitis in rats","authors":"Pratap K Khunti, Samir Rabadiya, Jalpa Sanandiya, S. Parmar","doi":"10.15406/ppij.2021.09.00347","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00347","url":null,"abstract":"Background/objectives: Acute pancreatitis (AP) is characterized by tissue edema, acinar necrosis, hemorrhage, and fat necrosis, as well as inflammation and perivascular infiltration in the pancreas. Serum triglyceride levels more than 1000 mg/dl are accountable for AP. Ginger extract has been reported to reduce the triglyceride level in diabetic rats. This study is aimed to determine the effect of ginger water extract on AP in rats. Methods: Hypertriglyceridemic-AP was induced by poloxamer 407 (0.7 gm/kg) in Wistar rats. The treatment of ginger water extract was given in two groups with doses of 200 and 400 mg/kg in the rats. The effect of ginger water extract on serum blood glucose, triglyceride, and lipoprotein profile was estimated to access its lipid-lowering properties. The effect of ginger water extract on lipid peroxidation, superoxide dismutase, catalase, and glutathione was also studied. Results: Ginger extract showed significantly reduced blood glucose, triglyceride, total cholesterol, α-amylase, and increased good cholesterol levels compared to the disease control group that indicated beneficial lipid-lowering properties. Furthermore, ginger water extract was also significantly reduced lipid peroxidation and enhanced superoxide dismutase, catalase, and glutathione levels as compared with the disease control group. Conclusion: In conclusion, the ameliorative effect of ginger extract against poloxamer 407 induced HTG-AP. Demonstrated lipid-lowering and antioxidant properties of ginger extract. The present study, showed protective effect of ginger against Acute Pancreatitis in rats.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"201 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82826435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylaxis of malaria by Artemisia infusions: The key role of lysine","authors":"P. Lutgen","doi":"10.15406/ppij.2021.09.00346","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00346","url":null,"abstract":"Since several years we try to understand why Artemisia infusions show a very efficient prophylaxis against malaria. This has been noticed in clinical trials and anecdotic reports in several African countries. Patrick Ogwang in his seminal work finds that Artemisia annua infusion consumed once a week is effective in preventing multiple episodes of malaria attacks and its mode of action may involve stimulation of white blood cells production especially monocytes.1 We have proposed several hypotheses, but were so far unable to verify them in vivo.2,3 Another hypothesis was based on the oxidative weakening of sporozoites by NO generated by arginine. Scientific papers on this topic are scarce.4,5 Another explanation for the prophylactic effect is resting on the high concentration of fatty acids in medicinal plants, and particularly polyunsaturated fatty acids (PUFA). Preliminary studies had indicated to a research team in Norway a suppressive influence of fish oils on rodent malaria.6","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87880553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo studies to manifest the potent antiinflammatory and analgesic effect of the topical formulation, Pankajakasthuri orthoherb cream/ thermagel upon single application in wistar albino rats","authors":"Shan Sasidharan, Hareendran Nair J","doi":"10.15406/ppij.2021.09.00345","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00345","url":null,"abstract":"Pain and inflammation are the most common and prominent symptoms of many diseases. Inflammation is the most pivotal response of a damaged tissue that induces various hostile stimuli such as infections, toxic chemical agents, and physical damage resulting in redness, edema, heat, and pain. Diclofenac sodium is the most widely prescribed medicine in the management of pain and inflammation. Lamentably, long-term use of this drug causes multiple harmful side effects. To overcome this, we have formulated Pankajakasthuri orthoherb cream/thermagel, a polyherbal topical preparation for inflammation and pain relief. The objective of the present study was to assess the anti-inflammatory and analgesic potential of Pankajakasthuri orthoherb cream/thermagel , when administered topically, using carrageenan-induced edema and formalin testing in experimental animals. Here, diclofenac sodium gel was used as a positive control for anti-inflammatory and analgesic activity. From the results of our study, it was clear that Pankajakasthuri orthoherb cream/ thermagel significantly inhibited the formation of the rat paw edema and this effect was significantly better than standard diclofenac sodium gel. Pankajakasthuri orthoherb cream/ thermagel recorded a positive result after 3 h of treatment and maximum reduction in edema was recorded after 18 h of treatment (96.72%). The analgesic effect of Pankajakasthuri orthoherb cream/thermagel was recorded mainly in the late phase (70.70%). This suggests that the activity may be due to peripheral action, when compared with the action of diclofenac sodium gel. Hence it can be concluded that Pankajakasthuri orthoherb cream/ thermagel can result in better anti-inflammatory and analgesic action for a longer duration upon single application compared with standard diclofenac sodium gel.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88907119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pongamia pinnata: an updated review on its phytochemistry, & pharmacological uses","authors":"Saurabh Nimesh, M. Akram, Muhammad Amjad Chishti, Md. Iftekhar Ahmad, Shikha Dhama, M. Lal","doi":"10.15406/ppij.2021.09.00344","DOIUrl":"https://doi.org/10.15406/ppij.2021.09.00344","url":null,"abstract":"P. pinnata, Pongamia pinnata; E. coli, Escherichia coli; PPEt, Pongamia pinnata leaf extract; HSV, herpes simplex virus; BW, body weight; IP, Intraperitoneal; PPSB, Pongamia pinnata stem bark; P. aeruginosa, Pseudomonas aeruginosa; S. aureus Staphylococcus aureus Abstract The term herb is also acknowledged as botanical medication or usage of herb-based traditional medicinal practice in herbal medicine, and it refers to a herb or plant component that is utilized to formulate remedy to aid in the therapeutic procedure through sickness and ailment. Medicinal plants play an important role in both herbal medicine and modern pharmaceuticals. Pongamia pinnata (P. pinnata) has been recognized in different schemes of herbal medication for the treatment of a variety of diseases and ailments in humans. It comprises a variety of phytoconstituents and has a broad variety of pharmacological properties. Because of its thick network of lateral roots, it is a favored plant for managing earth corrosion and connecting sand mounds. The most significant properties of P. pinnata is that it can be used as biofuel besides used in the treatment of many diseases like cancers, stiff joints, hemorrhoids, bowel movement, vaginopathy, wound healing, cardioprotective, etc. This analysis examines existing knowledge of common uses, phytochemistry, and biological activities, as well as limitations that require future study.","PeriodicalId":19839,"journal":{"name":"Pharmacy & Pharmacology International Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80193231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}