Efficacy and safety of a daytime anxiolytic containing technologically processed antibodies to the S100 protein. Overview of clinical studies

M. Perez, N. Zavadenko, L. Skipetrova, I. I. Smirnov, Y. Nesterovskiy
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Abstract

The review presents the results of clinical studies of the efficacy and safety of Tenoten and Tenoten children’s in the treatment of anxiety, neurotic, stress-related and somatoform disorders and adjustment disorders. Technologically processed antibodies to the S100 protein in Tenoten and Tenoten children’s drugs change the conformation of the S100 protein, which is considered as a pathological link in the development of anxiety states, as well as neurodegenerative diseases. Tenoten is a well-studied daytime anxiolytic that combines a favorable safety profile with high anxiolytic activity. The efficacy of Tenoten in the treatment of anxiety disorders is comparable to that of benzodiazepine drugs. Tenoten has no inhibitory and muscle relaxant effects, does not cause drug tolerance, addiction, "withdrawal" syndrome, as well as drug interactions. Tenoten for children has been shown to be effective in the treatment of anxiety in children, including those with somatic manifestations, attention deficit hyperactivity disorder, and learning disabilities.
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含有技术处理的S100蛋白抗体的日间抗焦虑药的有效性和安全性。临床研究综述
本文综述了Tenoten和Tenoten儿童在治疗焦虑、神经症、应激相关和躯体形式障碍以及适应障碍方面的有效性和安全性的临床研究结果。Tenoten和Tenoten儿童药物中针对S100蛋白的技术处理抗体改变了S100蛋白的构象,这被认为是焦虑状态和神经退行性疾病发展的病理联系。Tenoten是一种经过充分研究的日间抗焦虑药,具有良好的安全性和高抗焦虑活性。Tenoten治疗焦虑症的疗效与苯二氮卓类药物相当。Tenoten没有抑制和肌肉松弛作用,不会引起药物耐受性、成瘾性、“戒断”综合征以及药物相互作用。儿童用Tenoten已被证明对治疗儿童焦虑有效,包括那些有躯体表现、注意缺陷多动障碍和学习障碍的儿童。
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