M. V. Savitskii, N. Moskaleva, N. A. Zigangirova, A. Soloveva, A. Sheremet, N. Bondareva, N. L. Lubenec, N. V. Pyatigorskaya, S. Appolonova
{"title":"Experimental Pharmacokinetics, Metabolism and Tissue Distribution Studies Fluorothiazinon, a of Novel Antivirulence Drug","authors":"M. V. Savitskii, N. Moskaleva, N. A. Zigangirova, A. Soloveva, A. Sheremet, N. Bondareva, N. L. Lubenec, N. V. Pyatigorskaya, S. Appolonova","doi":"10.33647/2074-5982-19-1-73-84","DOIUrl":null,"url":null,"abstract":"We studied the pharmacokinetics, tissue availability and metabolism of fluorothiazinon, a novel antivirulence drug, in mouse blood, liver, kidneys and lungs by administering the substance intragastrically at dose of 400 mg/kg. Fluorothiazinon was established to exhibit good tissue availability and long residential time. This drug is metabolized mainly by glucuronidation.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"19 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal Biomed","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33647/2074-5982-19-1-73-84","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We studied the pharmacokinetics, tissue availability and metabolism of fluorothiazinon, a novel antivirulence drug, in mouse blood, liver, kidneys and lungs by administering the substance intragastrically at dose of 400 mg/kg. Fluorothiazinon was established to exhibit good tissue availability and long residential time. This drug is metabolized mainly by glucuronidation.
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