A Review on Novel Approach of Gastro-Retentive Oral Drug Delivery System

Abstract

The primary goal of this review is to examine and test the efficacy of new gastroretentive techniques for dealing with drugs that are without difficulty absorbed from the gastrointestinal tract and have very short half-lives that are rapidly removed from the systemic circulation. To have an excellent therapeutic effect, these drugs must be taken frequently. A systematic search and collection of reviewed information from Pubmed, Embase, Scopus, and Scholar databases were searched from inception to identify studies on current medications. Several methods are used to retain the drug and enhancethe bioavailability, conventional effect versus floating effect. The current approaches of floating drug delivery systems can be used to reduce complex tasks associated with conventional oral dose forms and release the drug at a specific absorption site, which has been shown in these reviews to be effective in targeting drug release at a specific absorption site to improve the bioavailability of a specific drug material. Based on the data presented, the conclusion is that it can also provide local medication delivery in the stomach and proximal small intestine. To achieve the system with the intended activity, it is critical to select the right technology for the right goal via asuitable mechanism of action. These technologies can solve various problems while improving a pharmaceutical dosage form.