An analysis of the microstructure of white matter in migrain: a pilot study

Abstract

White matter microstructure imaging has long been studied and analyzed with tensor diffusion pulse sequences. White matter integrity analysis has been performed on many different groups of cranial neuropathies. Migraine is a typical unilateral pulsating headache disorder. Although the prevalence of migraine is very high, the pathophysiology is still unclear. From the hypothesis, migraine and persistent migraine may affect the white matter microstructure image. Based on the diffusion of water molecules in the white matter nerve fiber bundle, and the connection to the “pain matrix”. Tract-based spatial statistics (TBSS) can demonstrate whether or not there is a difference in the water diffusion characteristics of fiber bundles in migraine patients compared with healthy volunteers. We conducted a pilot study to understand the TBSS analysis and white matter microstructure analysis in patients diagnosed with migraine. Key words: migrain, microstructures, white matter intergrity, DTI, TBSS