Long Nguyen Hoang, Thao Tran Thi, Thảo Hoàng Thị Phương, Linh Pham Thi Khanh, Duc Ton Nu Minh, Phuong Nguyen Thi Anh, Trang Ho Thi Thuy
Background: Experiences of performing scientific research are significantly to enhance nursing evidence-based practice. This study aimed to describe the current status of scientific research of nursing students, and identify attitudes of nursing students toward scientific research at Hue University of Medicine and Pharmacy, Hue University. Materials and methods: Retrospective study and a cross-sectional study design were used. A sample of 47 Bachelor’s thesis in nursing and 516 nursing students at University of Medicine and Pharmacy, Hue University was involved. Data were collected using a questionnaire, which including: (1) General characteristics, (2) “Critical appraisal checklist for cross-sectional study toolkit”, and (3) “The Nursing students’ attitudes towards and awareness of research and development within nursing scale”. Multivariable regression analyses were used to find the associated factors of attitude toward scientific research. Results: Most of undergraduate theses ensure quality assurance in research. Overall, attitude of scientific research among nursing students is moderate. Year of study, ranked academic, read scientific research regularly, and plan to participate in scientific research were significantly associated with attitudes toward scientific research. Conclusion: There is a need to motivate nursing students to participate in scientific activities through provide research and offer opportunities for them to do scientific research.
{"title":"Current status of scientific research of nursing students at Hue University of Medicine and Pharmacy","authors":"Long Nguyen Hoang, Thao Tran Thi, Thảo Hoàng Thị Phương, Linh Pham Thi Khanh, Duc Ton Nu Minh, Phuong Nguyen Thi Anh, Trang Ho Thi Thuy","doi":"10.34071/jmp.2023.4.2","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.2","url":null,"abstract":"Background: Experiences of performing scientific research are significantly to enhance nursing evidence-based practice. This study aimed to describe the current status of scientific research of nursing students, and identify attitudes of nursing students toward scientific research at Hue University of Medicine and Pharmacy, Hue University.\u0000\u0000Materials and methods: Retrospective study and a cross-sectional study design were used. A sample of 47 Bachelor’s thesis in nursing and 516 nursing students at University of Medicine and Pharmacy, Hue University was involved. Data were collected using a questionnaire, which including: (1) General characteristics, (2) “Critical appraisal checklist for cross-sectional study toolkit”, and (3) “The Nursing students’ attitudes towards and awareness of research and development within nursing scale”. Multivariable regression analyses were used to find the associated factors of attitude toward scientific research.\u0000\u0000Results: Most of undergraduate theses ensure quality assurance in research. Overall, attitude of scientific research among nursing students is moderate. Year of study, ranked academic, read scientific research regularly, and plan to participate in scientific research were significantly associated with attitudes toward scientific research.\u0000\u0000Conclusion: There is a need to motivate nursing students to participate in scientific activities through provide research and offer opportunities for them to do scientific research.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82233296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nga Vo Thi Bich, May Nguyen Thi, Binh Vo Thi Diem, Trang Ho Thi Thuy, Phuong Nguyen Thi Anh
Background: Utilizing Ubiquitous - Based Learning (UBL) in health education within the hospital setting has practical support for the patient’s care. However, the application of technology in health education programs in a hospital environment is still limited. Objectives: This study aimed to evaluate the effectiveness and applicability of UBL in the post-operative care of gastrointestinal cancer surgery for patients’ family caregivers at Department of Surgery 1, Da Nang Oncology Hospital from April 2020 to February 2022. Materials and method: A quasi-experimental study was conducted on 70 family members of patients being treated after gastrointestinal cancer surgery at Department of Surgery 1, Da Nang Oncology Hospital. Results: The effectiveness of UBL: The findings revealed no significant difference between the two groups’ knowledge scores before the intervention. However, the post-test mean scores increased in both groups; in which, the intervention group’s mean score of knowledge was significantly greater compared to the control group with 3.23 ± 0.84 and 1.82 ± 0.92 respectively (p < 0.05). The applicability of UBL: All family members agreed and completely agreed on the features of UBL in family health education about caring for patients after gastrointestinal cancer surgery. Conclusion: The teaching method utilizing UBL is significantly more effective than traditional teaching methods, and it is necessary to enhance its application in health education in hospitals and the community. Key words: Ubiquitous-based Learning, Health education, gastrointestinal cancer surgery.
{"title":"Evaluating the effectiveness and applicability of ubiquitous-based learning about post-operative care of gastrointestinal cancer surgery for patients’ family caregivers","authors":"Nga Vo Thi Bich, May Nguyen Thi, Binh Vo Thi Diem, Trang Ho Thi Thuy, Phuong Nguyen Thi Anh","doi":"10.34071/jmp.2023.4.4","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.4","url":null,"abstract":"Background: Utilizing Ubiquitous - Based Learning (UBL) in health education within the hospital setting has practical support for the patient’s care. However, the application of technology in health education programs in a hospital environment is still limited.\u0000\u0000Objectives: This study aimed to evaluate the effectiveness and applicability of UBL in the post-operative care of gastrointestinal cancer surgery for patients’ family caregivers at Department of Surgery 1, Da Nang Oncology Hospital from April 2020 to February 2022. Materials and method: A quasi-experimental study was conducted on 70 family members of patients being treated after gastrointestinal cancer surgery at Department of Surgery 1, Da Nang Oncology Hospital.\u0000\u0000Results: The effectiveness of UBL: The findings revealed no significant difference between the two groups’ knowledge scores before the intervention. However, the post-test mean scores increased in both groups; in which, the intervention group’s mean score of knowledge was significantly greater compared to the control group with 3.23 ± 0.84 and 1.82 ± 0.92 respectively (p < 0.05). The applicability of UBL: All family members agreed and completely agreed on the features of UBL in family health education about caring for patients after gastrointestinal cancer surgery.\u0000\u0000Conclusion: The teaching method utilizing UBL is significantly more effective than traditional teaching methods, and it is necessary to enhance its application in health education in hospitals and the community.\u0000\u0000Key words: Ubiquitous-based Learning, Health education, gastrointestinal cancer surgery.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87797992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phuong Vo Thi Hong, Quyen Nguyen Thi Ngoc, Cuc Ngo Thi Kim, Anh Phan Dang Thuc, Huong Hoang Thi Lan, Ngoc Nguyen Phuoc Bich
Background: Asthma is either a chronic respiratory disease or a serious global health problem that is common in all ages at a high rate. It seriously affects not only the physical health but also the health-related quality of life (HRQoL) of patients. Objectives: (1) To determine HRQoL score among asthmatic outpatients at Hue University of Medicine and Pharmacy Hospital; (2) To assess factors associated with HRQoL among asthmatic outpatients at Hue University of Medicine and Pharmacy Hospital. Subjects and methods: A descriptive cross-sectional study was conducted on 102 asthmatic outpatients at Hue University of Medicine and Pharmacy Hospital by using a self-administered questionnaire. Results: The male-to-female patient ratio was 1.68/1. The mean age of study participants was 59.2 ± 15.39 (26-95). A large number of patients were unemployed (55.9%) and had a low education level (54.9%). Participants with comorbidities and time of being diagnosed with asthma over 10 years accounted for the highest percentage, 69.6%, and 48.0% respectively, but most patients were not hospitalized due to an acute asthma attack within the past year (88.2%). The most common type of inhaler being used was DPI or the combination of MDI and DPI (35.3%) whereas the prevalence of patients only using the Metered-Dose Inhalers (MDI) was 29.4%. There were 40.2% of patients who were severely affected. The mean value of the total HRQoL score was 4.27 ± 0.747. The domain that most impacted HRQoL was “Activity limitations” whereas “Symptoms” affected the least. Men had higher HRQoL than women (6.441 times); The participants who did not have asthma-related family history were likely to have better HRQoL than others (3.3 times); The patients who used MDI or DPI alone had higher HRQoL scores than the group used the combination of two devices (2.788 times). Conclusions: Asthma remarkably affected asthmatic patients’ quality of life. The factors associated with HRQoL were gender, family history of asthma, and the type of inhaler. Key words: sthma, health-related quality of life, outpatients, Hue University of Medicine and Pharmacy Hospital.
{"title":"Assessment of health-related quality of life among outpatients with asthma at Hue University of Medicine and Pharmacy Hospital","authors":"Phuong Vo Thi Hong, Quyen Nguyen Thi Ngoc, Cuc Ngo Thi Kim, Anh Phan Dang Thuc, Huong Hoang Thi Lan, Ngoc Nguyen Phuoc Bich","doi":"10.34071/jmp.2023.4.11","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.11","url":null,"abstract":"Background: Asthma is either a chronic respiratory disease or a serious global health problem that is common in all ages at a high rate. It seriously affects not only the physical health but also the health-related quality of life (HRQoL) of patients. \u0000\u0000Objectives: (1) To determine HRQoL score among asthmatic outpatients at Hue University of Medicine and Pharmacy Hospital; (2) To assess factors associated with HRQoL among asthmatic outpatients at Hue University of Medicine and Pharmacy Hospital. Subjects and methods: A descriptive cross-sectional study was conducted on 102 asthmatic outpatients at Hue University of Medicine and Pharmacy Hospital by using a self-administered questionnaire. \u0000\u0000Results: The male-to-female patient ratio was 1.68/1. The mean age of study participants was 59.2 ± 15.39 (26-95). A large number of patients were unemployed (55.9%) and had a low education level (54.9%). Participants with comorbidities and time of being diagnosed with asthma over 10 years accounted for the highest percentage, 69.6%, and 48.0% respectively, but most patients were not hospitalized due to an acute asthma attack within the past year (88.2%). The most common type of inhaler being used was DPI or the combination of MDI and DPI (35.3%) whereas the prevalence of patients only using the Metered-Dose Inhalers (MDI) was 29.4%. There were 40.2% of patients who were severely affected. The mean value of the total HRQoL score was 4.27 ± 0.747. The domain that most impacted HRQoL was “Activity limitations” whereas “Symptoms” affected the least. Men had higher HRQoL than women (6.441 times); The participants who did not have asthma-related family history were likely to have better HRQoL than others (3.3 times); The patients who used MDI or DPI alone had higher HRQoL scores than the group used the combination of two devices (2.788 times). \u0000\u0000Conclusions: Asthma remarkably affected asthmatic patients’ quality of life. The factors associated with HRQoL were gender, family history of asthma, and the type of inhaler.\u0000\u0000Key words: sthma, health-related quality of life, outpatients, Hue University of Medicine and Pharmacy Hospital.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75985125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nhan Ho Hoang, Hao Le Hoang, Hue Ho Thi Thu, Ngoc Phan Thi Thao
Background: Periodontitis is a chronic bacterial infection destroying tooth-supporting tissues. Like metronidazole, tinidazole (TNZ) is also effective in treating periodontitis. The preparation of polymeric nanoparticles containing TNZ helps to improve the solubility and increase the bioavailability of the drug. Objectives: This study aimed to formulate and optimize TNZ nanoparticles and evaluate their physicochemical properties. Materials and methods: TNZ, Eudragit RSPO polymer as a carrier were used in this study. TNZ-loaded nanoparticles (TNZ NPs) were prepared by the solvent evaporation - emulsion method. The influence of the factors in the formula and the preparation process of TNZ NPs was investigated and optimized using MODDE 13.0 software. The physicochemical properties of NPs were evaluated by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and in vitro drug release. Result: The optimal TNZ NPs were spherical in shape, mostly amorphous, with particle size of 179.60 ± 2.20 nm, polydispersity index of 0.149 ± 0.024, and encapsulation efficiency of 47.49 ± 0.02%. TNZ NPs showed prolonged drug release in phosphate buffer pH 6.8 for up to 24 hours. Conclusions: The optimal TNZ NPs would be a promising drug delivery system for periodontitis treatment. Key words: tinidazole, nanoparticle, periodontitis.
{"title":"Optimization and physicochemical characterization of polymeric nanoparticles containing tinidazole","authors":"Nhan Ho Hoang, Hao Le Hoang, Hue Ho Thi Thu, Ngoc Phan Thi Thao","doi":"10.34071/jmp.2023.4.9","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.9","url":null,"abstract":"Background: Periodontitis is a chronic bacterial infection destroying tooth-supporting tissues. Like metronidazole, tinidazole (TNZ) is also effective in treating periodontitis. The preparation of polymeric nanoparticles containing TNZ helps to improve the solubility and increase the bioavailability of the drug.\u0000\u0000Objectives: This study aimed to formulate and optimize TNZ nanoparticles and evaluate their physicochemical properties. Materials and methods: TNZ, Eudragit RSPO polymer as a carrier were used in this study. TNZ-loaded nanoparticles (TNZ NPs) were prepared by the solvent evaporation - emulsion method. The influence of the factors in the formula and the preparation process of TNZ NPs was investigated and optimized using MODDE 13.0 software. The physicochemical properties of NPs were evaluated by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and in vitro drug release.\u0000\u0000Result: The optimal TNZ NPs were spherical in shape, mostly amorphous, with particle size of 179.60 ± 2.20 nm, polydispersity index of 0.149 ± 0.024, and encapsulation efficiency of 47.49 ± 0.02%. TNZ NPs showed prolonged drug release in phosphate buffer pH 6.8 for up to 24 hours.\u0000\u0000Conclusions: The optimal TNZ NPs would be a promising drug delivery system for periodontitis treatment.\u0000\u0000Key words: tinidazole, nanoparticle, periodontitis.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79334399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thang Tran Binh, Phuong Ho Uyen, Lieu Dinh Thi, Ha Pham Thi Thu, Dan Chau Nguyen, Khuyen Nguyen Ngo Bao, Tham Luong Thi Thu, My Tran Thi Tra, Duc Vo Nu Hong, Gia Nguyen Thanh, Thong Nguyen Van, Tam Nguyen Minh, Tu Nguyen Minh
Background: Adolescents who live in incomplete families may be vulnerable to various psychological effects, ranging from mild to complex. This study aims to examine the need for psychological counseling among high school students whose parents are separated/divorced, and to identify factors associated with this need. Methods: A cross-sectional descriptive study was conducted on 309 high school students with separated/separated/divorced parents in Hue City. Results: The percentage of high school students with separated/divorced parents who need psychological counseling accounted for 40.5%. The need for psychological consultation about life skills and future orientation accounted for 54.4%, appearance and physicality accounted for 37.9%, family relationships accounted for 33.0% and problems with reproductive health and heterosexual friendship accounted for 31.4%. Factors related to the need for psychological counseling include the time of parents’ divorce, close friendship relationship, problems with friends, behavioral problems, violence, family quality and school quality, with a significance level of p < 0.05. Conclusion: High school students with separated/divorced parents need psychological counseling, so it is necessary to combine family and school to create a healthy environment for children Key words: psychological counseling, needs, students, parents separated/divorced.
{"title":"Psychological counseling needs among middle and high school students with separated/divorced parents in Hue city","authors":"Thang Tran Binh, Phuong Ho Uyen, Lieu Dinh Thi, Ha Pham Thi Thu, Dan Chau Nguyen, Khuyen Nguyen Ngo Bao, Tham Luong Thi Thu, My Tran Thi Tra, Duc Vo Nu Hong, Gia Nguyen Thanh, Thong Nguyen Van, Tam Nguyen Minh, Tu Nguyen Minh","doi":"10.34071/jmp.2023.4.13","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.13","url":null,"abstract":"Background: Adolescents who live in incomplete families may be vulnerable to various psychological effects, ranging from mild to complex. This study aims to examine the need for psychological counseling among high school students whose parents are separated/divorced, and to identify factors associated with this need.\u0000\u0000Methods: A cross-sectional descriptive study was conducted on 309 high school students with separated/separated/divorced parents in Hue City.\u0000\u0000Results: The percentage of high school students with separated/divorced parents who need psychological counseling accounted for 40.5%. The need for psychological consultation about life skills and future orientation accounted for 54.4%, appearance and physicality accounted for 37.9%, family relationships accounted for 33.0% and problems with reproductive health and heterosexual friendship accounted for 31.4%. Factors related to the need for psychological counseling include the time of parents’ divorce, close friendship relationship, problems with friends, behavioral problems, violence, family quality and school quality, with a significance level of p < 0.05.\u0000\u0000Conclusion: High school students with separated/divorced parents need psychological counseling, so it is necessary to combine family and school to create a healthy environment for children\u0000\u0000Key words: psychological counseling, needs, students, parents separated/divorced.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76248060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Preterm premature rupture of membranes is defined as rupture of membranes before the onset of labor with the gestational age < 37 weeks. Preterm premature rupture of membranes is associated with 10% of the perinatal mortality, particularly associated with respiratory distress syndrome and neonatal infection. Objective: The study aims to assess the outcome of maternal and fetal outcome in preterm premature rupture of membranes. Materials and Methods: This cross-sectional study was performed on 136 pregnant women complicated by preterm premature rupture of membranes during May 2020 to June 2022 at Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital. The pregnant women were managed to accord the current clinical practice of hospital. The information about objects is recorded until the time of discharge. Results: The rate of vaginal delivery is 52.9% and intra-amniotic infection is 8.8%. The gestational age < 34 weeks and closed cervix are associated with a greater frequency of cesarean section. The rate of neonatal infection is 34%, respiratory failure is 30%. The gestational age < 34 weeks and prolonged duration of membrane rupture to delivery > 48 hours increase the risk of early neonatal infection and neonatal respiratory failure, while the delivery methods are not increased these risks. Conclusion: Our findings provide insights to physicians when counseling parents on preterm premature rupture of membranes at periviable gestational age.
{"title":"Maternal and neonatal outcome in preterm premature rupture of membranes","authors":"Giang Truong Thi Linh, Tan Vo Quang","doi":"10.34071/jmp.2023.4.3","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.3","url":null,"abstract":"Background: Preterm premature rupture of membranes is defined as rupture of membranes before the onset of labor with the gestational age < 37 weeks. Preterm premature rupture of membranes is associated with 10% of the perinatal mortality, particularly associated with respiratory distress syndrome and neonatal infection.\u0000\u0000Objective: The study aims to assess the outcome of maternal and fetal outcome in preterm premature rupture of membranes. Materials and Methods: This cross-sectional study was performed on 136 pregnant women complicated by preterm premature rupture of membranes during May 2020 to June 2022 at Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital. The pregnant women were managed to accord the current clinical practice of hospital. The information about objects is recorded until the time of discharge.\u0000\u0000Results: The rate of vaginal delivery is 52.9% and intra-amniotic infection is 8.8%. The gestational age < 34 weeks and closed cervix are associated with a greater frequency of cesarean section. The rate of neonatal infection is 34%, respiratory failure is 30%. The gestational age < 34 weeks and prolonged duration of membrane rupture to delivery > 48 hours increase the risk of early neonatal infection and neonatal respiratory failure, while the delivery methods are not increased these risks.\u0000\u0000Conclusion: Our findings provide insights to physicians when counseling parents on preterm premature rupture of membranes at periviable gestational age.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78789172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nhan Ho Hoang, Ngoc Le Thi Thanh, Hao Le Hoang, Ny Tran Thi Kieu, Tuan Dao Anh
Background: Periodontitis is a chronic inflammation of the periodontal tissues. To increase the effectiveness of treatment, antibiotics selected should have a spectrum of action on bacteria causing periodontitis, while also meeting the requirements of cell penetration and prolonging of the retention time at the target site. Therefore, this study aimed at developing solid lipid nanoparticles (SLNs) containing tinidazole (TNZ-SLNs) oriented to be incorporated into the gel to increase the penetration ability and prolong drug retention time in periodontal tissues. Objectives: Therefore, this study aimed to develop and characterize solid lipid nanoparticles (SLNs) containing tinidazole (TNZ-SLNs) oriented to be incorporated into the gel to increase the penetration ability and prolong drug retention time in periodontal tissues. Methods: TNZ-SLNs were prepared by combining hot homogenization and solvent evaporation using different types of lipids and surfactants. Factors related to the formula and the preparation process were investigated, Design Expert 12.0, FormRules v2.0 and InForm v3.1 software were used to design experiments and optimize the formula. The prepared nanoparticles were characterized by particle size, polydispersity index (PDI), encapsulation efficiency (EE), etc. Results: The optimized formulation had a particle size of 197.60 ± 19.67 nm, a PDI of 0.247 ± 0.011, a zeta potential of -15.79 ± 0.75mV and an EE of 37.96 ± 0.91%. TNZ-SLNs showed prolonged in vitro drug release (for up to 24 hours), while TNZ material achieved about 100% drug release after 4 hours. Conclusion: TNZ-SLNs were successfully fabricated and physicochemically characterized. Key words: Tinidazole, solid lipid nanoparticles, periodontitis.
{"title":"Development and physicochemical characterization of solid lipid nanoparticles containing tinidazole","authors":"Nhan Ho Hoang, Ngoc Le Thi Thanh, Hao Le Hoang, Ny Tran Thi Kieu, Tuan Dao Anh","doi":"10.34071/jmp.2023.4.12","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.12","url":null,"abstract":"Background: Periodontitis is a chronic inflammation of the periodontal tissues. To increase the effectiveness of treatment, antibiotics selected should have a spectrum of action on bacteria causing periodontitis, while also meeting the requirements of cell penetration and prolonging of the retention time at the target site. Therefore, this study aimed at developing solid lipid nanoparticles (SLNs) containing tinidazole (TNZ-SLNs) oriented to be incorporated into the gel to increase the penetration ability and prolong drug retention time in periodontal tissues. \u0000\u0000Objectives: Therefore, this study aimed to develop and characterize solid lipid nanoparticles (SLNs) containing tinidazole (TNZ-SLNs) oriented to be incorporated into the gel to increase the penetration ability and prolong drug retention time in periodontal tissues.\u0000\u0000Methods: TNZ-SLNs were prepared by combining hot homogenization and solvent evaporation using different types of lipids and surfactants. Factors related to the formula and the preparation process were investigated, Design Expert 12.0, FormRules v2.0 and InForm v3.1 software were used to design experiments and optimize the formula. The prepared nanoparticles were characterized by particle size, polydispersity index (PDI), encapsulation efficiency (EE), etc. Results: The optimized formulation had a particle size of 197.60 ± 19.67 nm, a PDI of 0.247 ± 0.011, a zeta potential of -15.79 ± 0.75mV and an EE of 37.96 ± 0.91%. TNZ-SLNs showed prolonged in vitro drug release (for up to 24 hours), while TNZ material achieved about 100% drug release after 4 hours.\u0000\u0000Conclusion: TNZ-SLNs were successfully fabricated and physicochemically characterized.\u0000\u0000Key words: Tinidazole, solid lipid nanoparticles, periodontitis.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"71 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83680557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinh Nguyen Cong, Vui Tran Van, Thu Nguyen Thi Dang, Thu Dang Thi Anh
Background: Proper management of medical solid waste (MSW) is a complex global challenge that affects healthcare workers (HW), patients, and the environment. This study aims to evaluate the knowledge and practices of HW regarding MSW management and explore the factors associated with their knowledge and practices at the Quang Nam Northern Mountainous Region General Hospital in 2020. Materials and method: A cross-sectional study was conducted on 478 HW from June to December 2020. A self-administered questionnaire was used to collect general and knowledge information, while a checklist was used to assess their practices. Multivariate logistic regressions were conducted to identify the factors associated with knowledge and practices. Results: Out of the 478 respondents, 71.1% had good general knowledge, and 75.9% had good practices regarding MSW management. Multivariate logistic regressions showed that knowledge was significantly associated with age group (OR = 14.69; 95%CI = 5.87 - 36.77 and OR = 44.26; 95%CI = 12.04 - 162.74, p < 0.001), occupation (OR = 22.78; 95%CI = 4.39 - 118.38 and OR = 18.09; 95%CI = 3.81 - 85.90, p < 0.001), training courses (OR = 0.21; 95%CI = 0.09 - 0.45 and OR = 0.24; 95%CI = 0.09 - 0.65, p < 0.05), and frequency of MSW monitoring activity (OR = 5.08; 95%CI = 2.18 - 10.87, p < 0.001). Similarly, practices were significantly associated with age group (OR = 3.36; 95%CI = 1.35 - 8.38, p < 0.05), working experience (OR = 0.49; 95%CI = 0.25 - 0.94, p < 0.05), and frequency of MSW monitoring activity (OR = 2.81; 95%CI = 1.63 - 4.85, p < 0.001). Furthermore, a positive association was observed between knowledge and practices regarding MSW management. Conclusion: Overall, the study found that the respondents had good knowledge and practices regarding MSW management. To maintain and improve this, the hospital should provide further training courses on MSW, ensure proper monitoring and supervision of managers and HW. Key words: medical solid waste management, knowledge, practice.
背景:医疗固体废物(MSW)的适当管理是一项复杂的全球性挑战，影响到卫生保健工作者(HW)、患者和环境。本研究旨在评估2020年广南北部山区总医院卫生工作者在城市固体废物管理方面的知识和实践，并探讨其知识和实践的相关因素。材料与方法:于2020年6月- 12月对478 HW进行横断面研究。使用自我管理的问卷收集一般和知识信息，而使用检查表来评估他们的做法。进行多变量逻辑回归以确定与知识和实践相关的因素。结果:在478名受访者中，71.1%对都市固体废物管理有良好的常识，75.9%对都市固体废物管理有良好的做法。多因素logistic回归分析显示，知识与年龄组显著相关(OR = 14.69;95%CI = 5.87 ~ 36.77, OR = 44.26;95%CI = 12.04 ~ 162.74, p < 0.001)、职业(OR = 22.78;95%CI = 4.39 ~ 118.38, OR = 18.09;95%CI = 3.81 ~ 85.90, p < 0.001)、培训课程(OR = 0.21;95%CI = 0.09 - 0.45, OR = 0.24;95%CI = 0.09 ~ 0.65, p < 0.05)，城市生活垃圾监测活动频率(OR = 5.08;95%CI = 2.18 ~ 10.87, p < 0.001)。同样，实践与年龄组显著相关(OR = 3.36;95%CI = 1.35 ~ 8.38, p < 0.05)、工作经验(OR = 0.49;95%CI = 0.25 ~ 0.94, p < 0.05)，城市生活垃圾监测活动频率(OR = 2.81;95%CI = 1.63 ~ 4.85, p < 0.001)。此外，我们观察到关于城市固体废物管理的知识和实践之间存在正相关关系。结论:总体而言，调查发现受访者对都市固体废物管理有良好的认识和实践。为了维持和改善这一点，医院应进一步提供关于都市固体废物的培训课程，确保对管理人员和卫生工作者进行适当的监测和监督。关键词:医疗固体废物管理，知识，实践。
{"title":"Knowledge and practice in respect of medical solid waste management among healthcare workers at Quang Nam Northern Mountainous Region General Hospital","authors":"Xinh Nguyen Cong, Vui Tran Van, Thu Nguyen Thi Dang, Thu Dang Thi Anh","doi":"10.34071/jmp.2023.4.5","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.5","url":null,"abstract":"Background: Proper management of medical solid waste (MSW) is a complex global challenge that affects healthcare workers (HW), patients, and the environment. This study aims to evaluate the knowledge and practices of HW regarding MSW management and explore the factors associated with their knowledge and practices at the Quang Nam Northern Mountainous Region General Hospital in 2020.\u0000\u0000Materials and method: A cross-sectional study was conducted on 478 HW from June to December 2020. A self-administered questionnaire was used to collect general and knowledge information, while a checklist was used to assess their practices. Multivariate logistic regressions were conducted to identify the factors associated with knowledge and practices.\u0000\u0000Results: Out of the 478 respondents, 71.1% had good general knowledge, and 75.9% had good practices regarding MSW management. Multivariate logistic regressions showed that knowledge was significantly associated with age group (OR = 14.69; 95%CI = 5.87 - 36.77 and OR = 44.26; 95%CI = 12.04 - 162.74, p < 0.001), occupation (OR = 22.78; 95%CI = 4.39 - 118.38 and OR = 18.09; 95%CI = 3.81 - 85.90, p < 0.001), training courses (OR = 0.21; 95%CI = 0.09 - 0.45 and OR = 0.24; 95%CI = 0.09 - 0.65, p < 0.05), and frequency of MSW monitoring activity (OR = 5.08; 95%CI = 2.18 - 10.87, p < 0.001). Similarly, practices were significantly associated with age group (OR = 3.36; 95%CI = 1.35 - 8.38, p < 0.05), working experience (OR = 0.49; 95%CI = 0.25 - 0.94, p < 0.05), and frequency of MSW monitoring activity (OR = 2.81; 95%CI = 1.63 - 4.85, p < 0.001). Furthermore, a positive association was observed between knowledge and practices regarding MSW management.\u0000\u0000Conclusion: Overall, the study found that the respondents had good knowledge and practices regarding MSW management. To maintain and improve this, the hospital should provide further training courses on MSW, ensure proper monitoring and supervision of managers and HW.\u0000\u0000Key words: medical solid waste management, knowledge, practice.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84554391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that has been strongly associated with atherosclerosis. Comprehensive cardiovascular disease (CVD) assessment is advised, which entails screening for asymptomatic atherosclerotic plaques using carotid ultrasound. The objective of this study is to examine the features of carotid ultrasound, including carotid intima-media thickness (cIMT) and carotid plaques (CP), and to compare these characteristics between individuals with RA and control subjects. Materials and Methods: A cross-sectional study involved 66 participants, including 40 RA patients and 26 controls. Medical history and physical examination were conducted by a rheumatologist, while cIMT and CP were recorded via carotid ultrasound. Results: cIMT was significantly higher in the RA group compared to the control group (0.94 (0.83 - 1.25) mm vs 0.84 (0.80 - 0.92) mm, p = 0.030) and the prevalence of increased cIMT was found significantly higher in RA-patients than non-RA patients (70.00% vs 38.46%, p = 0.011). Compared to non-RA patients, carotid plaques in the RA group were statistically more prevalent on either side of the carotid artery (left 57.50% vs. 26.92%, p = 0.015; right 67.50% vs 26.92%, p = 0.001) and bilateral CP was over three times more common in RA than controls (55.00% vs 15.38%, p = 0.001). cIMT was correlated with age and body mass index. Conclusion: The occurrence of subclinical atherosclerosis is higher among patients with RA than in the control participants without RA. Measuring cIMT and CP may be a useful guide to better assess CVD risk in patients with RA and enable clinicians to take interventions promptly. Key words: rheumatoid arthritis, cardiovascular diseases, carotid intima-media thickness, carotid plaques, carotid ultrasound.
背景:类风湿性关节炎(RA)是一种慢性炎症性疾病，与动脉粥样硬化密切相关。建议进行全面的心血管疾病(CVD)评估，包括使用颈动脉超声筛查无症状的动脉粥样硬化斑块。本研究的目的是检查颈动脉超声的特征，包括颈动脉内膜-中膜厚度(cIMT)和颈动脉斑块(CP)，并比较RA患者和对照组之间的这些特征。材料和方法:一项涉及66名参与者的横断面研究，包括40名RA患者和26名对照组。由风湿病专家进行病史和体格检查，颈动脉超声记录颈动脉ct和CP。结果:RA组的cIMT明显高于对照组(0.94 (0.83 - 1.25)mm vs 0.84 (0.80 - 0.92) mm, p = 0.030)， RA患者cIMT升高的发生率明显高于非RA患者(70.00% vs 38.46%， p = 0.011)。与非RA患者相比，RA组颈动脉斑块在颈动脉两侧更普遍(左57.50% vs. 26.92%， p = 0.015;(67.50% vs 26.92%， p = 0.001)，双侧CP在RA中的发生率是对照组的3倍以上(55.00% vs 15.38%， p = 0.001)。cIMT与年龄和体重指数相关。结论:类风湿关节炎患者亚临床动脉粥样硬化发生率高于非类风湿关节炎对照组。测量cIMT和CP可能是更好地评估RA患者心血管疾病风险的有用指南，并使临床医生能够及时采取干预措施。关键词:类风湿性关节炎，心血管疾病，颈动脉内膜-中膜厚度，颈动脉斑块，颈动脉超声
{"title":"Characteristics of the carotid intima-media thickness and atherosclerotic plaques of carotid arteries in elderly people with rheumatoid arthritis at University Medical Center Ho Chi Minh City","authors":"Ngoc Cao Thanh, Son Dang Ngoc","doi":"10.34071/jmp.2023.4.6","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.6","url":null,"abstract":"Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that has been strongly associated with atherosclerosis. Comprehensive cardiovascular disease (CVD) assessment is advised, which entails screening for asymptomatic atherosclerotic plaques using carotid ultrasound. The objective of this study is to examine the features of carotid ultrasound, including carotid intima-media thickness (cIMT) and carotid plaques (CP), and to compare these characteristics between individuals with RA and control subjects.\u0000\u0000Materials and Methods: A cross-sectional study involved 66 participants, including 40 RA patients and 26 controls. Medical history and physical examination were conducted by a rheumatologist, while cIMT and CP were recorded via carotid ultrasound.\u0000\u0000Results: cIMT was significantly higher in the RA group compared to the control group (0.94 (0.83 - 1.25) mm vs 0.84 (0.80 - 0.92) mm, p = 0.030) and the prevalence of increased cIMT was found significantly higher in RA-patients than non-RA patients (70.00% vs 38.46%, p = 0.011). Compared to non-RA patients, carotid plaques in the RA group were statistically more prevalent on either side of the carotid artery (left 57.50% vs. 26.92%, p = 0.015; right 67.50% vs 26.92%, p = 0.001) and bilateral CP was over three times more common in RA than controls (55.00% vs 15.38%, p = 0.001). cIMT was correlated with age and body mass index.\u0000\u0000Conclusion: The occurrence of subclinical atherosclerosis is higher among patients with RA than in the control participants without RA. Measuring cIMT and CP may be a useful guide to better assess CVD risk in patients with RA and enable clinicians to take interventions promptly.\u0000\u0000Key words: rheumatoid arthritis, cardiovascular diseases, carotid intima-media thickness, carotid plaques, carotid ultrasound.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86979324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Len Che Thi Len, Yen Hoang Thi Bach, Tam Nguyen Minh
Background: Undernutrition is a significant risk factor for mortality, complications, hospital infections, length of hospital stay, quality of life, and prognosis. Patients with proper nutrition will help prevent undernutrition, prevent the development of the disease, and improve the effectiveness of treatment. Nutrition is an integral part of the comprehensive treatment process. Nutritional risk screening is one criterion that shows the hospital’s nutritional care capacity. Assessing nutritional status plays an essential role in treating and recovering health. This study aims (1) to screen and assess the nutritional status of inpatients aged from 60 years old in Hue University Medicine and Pharmacy Hospital and (2) to identify some factors related to malnutrition. Methods: A cross-sectional study was carried out on 389 inpatients at two departments of internal medicine, Hue University of Medicine and Pharmacy Hospital, from 11/2020 - 03/2021. We used the mini nutritional assessment tool for screening nutrition risks. The subjective global assessment tool was used to assess nutritional status and questionnaires to understand some related factors. Results: There were 68.9% of patients at risk of malnutrition and 38.8% of patients had malnutrition. There were significant relationships between the nutrition status of patients with re-admitted status (p < 0.05), including diseases (p < 0.05), oral pathology (p < 0.05), decreased taste (p < 0.05). Conclusion: The prevalence of inpatients with nutritional risk in two departments of internal medicine was relatively high. It is necessary to conduct nutrition screening in all inpatients to improve the effectiveness of treatment and comprehensive care. Key words: malnutrition, inpatients, nutrition treatment, subjective global assessment tool, mini nutritional assessment tool.
{"title":"Risk screening, nutrition assessment and associated factors of malnutrition among elderly inpatients in Hue University of Medicine and Pharmacy Hospital","authors":"Len Che Thi Len, Yen Hoang Thi Bach, Tam Nguyen Minh","doi":"10.34071/jmp.2023.4.14","DOIUrl":"https://doi.org/10.34071/jmp.2023.4.14","url":null,"abstract":"Background: Undernutrition is a significant risk factor for mortality, complications, hospital infections, length of hospital stay, quality of life, and prognosis. Patients with proper nutrition will help prevent undernutrition, prevent the development of the disease, and improve the effectiveness of treatment. Nutrition is an integral part of the comprehensive treatment process. Nutritional risk screening is one criterion that shows the hospital’s nutritional care capacity. Assessing nutritional status plays an essential role in treating and recovering health.\u0000\u0000This study aims (1) to screen and assess the nutritional status of inpatients aged from 60 years old in Hue University Medicine and Pharmacy Hospital and (2) to identify some factors related to malnutrition.\u0000\u0000Methods: A cross-sectional study was carried out on 389 inpatients at two departments of internal medicine, Hue University of Medicine and Pharmacy Hospital, from 11/2020 - 03/2021. We used the mini nutritional assessment tool for screening nutrition risks. The subjective global assessment tool was used to assess nutritional status and questionnaires to understand some related factors.\u0000\u0000Results: There were 68.9% of patients at risk of malnutrition and 38.8% of patients had malnutrition. There were significant relationships between the nutrition status of patients with re-admitted status (p < 0.05), including diseases (p < 0.05), oral pathology (p < 0.05), decreased taste (p < 0.05).\u0000\u0000Conclusion: The prevalence of inpatients with nutritional risk in two departments of internal medicine was relatively high. It is necessary to conduct nutrition screening in all inpatients to improve the effectiveness of treatment and comprehensive care.\u0000\u0000Key words: malnutrition, inpatients, nutrition treatment, subjective global assessment tool, mini nutritional assessment tool.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82519645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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