C. Veeravel, K. Rajasekar, S. Balasubramaniyan, R. Selvarani
{"title":"Ex-vivo Antimalarial and in-vitro Biological Activities of newly synthesized Co(II) complex with Schiff base","authors":"C. Veeravel, K. Rajasekar, S. Balasubramaniyan, R. Selvarani","doi":"10.21608/EJCHEM.2021.55320.3166","DOIUrl":null,"url":null,"abstract":"The first-row transition metal complex of Schiff base has been synthesized and characterized based on physicochemical spectral and biochemical methods. The metal-ligand stoichiometry and molecular formula of the complex assessed by Elemental analysis and metal estimation-neutral, monomeric nature of the complex and paramagnetic nature also predict by the conductance and magnetic moment study. The octahedral environment around Co(II) and metal-imine bond as a whole predicted by atomic IR and Far-IR spectra. In-vitro antibacterial and antifungal activities of the Schiff base and its complexes compared with those for standard (Chloramphenicol & Fluconazole) by agar disc diffusion method. The Ex-vivo antimalarial activity of the Schiff base and its metal complex was found by using Plasmodium falciparum bacteria/fungal.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Egyptian Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/EJCHEM.2021.55320.3166","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The first-row transition metal complex of Schiff base has been synthesized and characterized based on physicochemical spectral and biochemical methods. The metal-ligand stoichiometry and molecular formula of the complex assessed by Elemental analysis and metal estimation-neutral, monomeric nature of the complex and paramagnetic nature also predict by the conductance and magnetic moment study. The octahedral environment around Co(II) and metal-imine bond as a whole predicted by atomic IR and Far-IR spectra. In-vitro antibacterial and antifungal activities of the Schiff base and its complexes compared with those for standard (Chloramphenicol & Fluconazole) by agar disc diffusion method. The Ex-vivo antimalarial activity of the Schiff base and its metal complex was found by using Plasmodium falciparum bacteria/fungal.
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