Evaluation and comparison of antioxidant status in ischemic and haemorrhagic cases of stroke

Abstract

Introduction:The World health organization (WHO) has well-defined stroke as “rapidly progressionof clinical signs of focal and at times global disturbances of cerebral function longlasting> 24 hours or resulting of death, with no apparent reason other than vascularregion.”Material and MethodsThis case-control study was conducted on an overall population of 200 individuals (58ischemic strokes and 29 haemorrhagic strokes as the case groups; 58 healthy individualsas the control group).Diagnosis: The diagnosis of stroke was based on history and clinical examination andbrain CT scan were used to confirm and classify ischemic and haemorrhagic strokecases.Results:A total of 200 cases of stroke (58 ischemic stroke, 29 haemorrhagic strokes, and 58healthy individuals as the control group) were identified during the study follow-up.GPX levels are reduced significantly in ISPs and HSPs equated with control subjects(p<0.001). Extreme decrease in GPX is seen in ISPs than HSPs(p<0.001).ConclusionFinally, positive direct relationship was seen in MDA along with infarct size. So,it could consider as a bio marker for recognising stroke. This could be valued forimproving the dose frequency for improvement of patient health. From these studies,we can conclude that antioxidant defence is reduced in ischemic stroke patients as asignificance of inclined oxidative stress.Key words: Oxidative stress–Antioxidant–Ischemic–Haemorrhagic