Recyclable Copper Oxide Catalyzed Synthesis of N -Arylpyrroles from Arylhalides and Trans-4-Hydroxy-L-Proline

Abstract

A facile and novel copper oxide nanoparticle catalyzed route has been developed for the synthesis of N-arylpyrroles, through tandem one-pot cross-coupling reaction of aryl halides and trans-4-hydroxy-L-proline, which is procured from natural source. This methodology is a first report of ligand free conditions and is a sustainable resource, via extrusion followed by redox amination. Catalyst used can be recovered and recycled up to five cycles with efficient activity.