{"title":"Linalool Glycosides from Flowers of Lantana montevidensis with Promising AntiInflammatory Potentials","authors":"Mohamed Nm, Malak Lg, Ross Sa","doi":"10.35248/2329-6836.20.8.375","DOIUrl":null,"url":null,"abstract":"Background and objective: Inflammation has been studied for thousands of years in an effort to mitigate its negative effects on the body. Analgesic and anti-inflammatory drugs were the primary concern in monoterpenes. Monoterpenes have been recognized for their ability to suppress inflammatory process and modulate the vital chemical mediators of inflammation, such as pro-inflammatory and anti-inflammatory cytokines. This study aimed to isolate the secondary metabolites of Lantana montevidensis (Verbenaceae) flowers and evaluate their in vitro antiinflammatory activity. Material and methods: Anti-inflammatory activity was done using TNF-α ELISA and NF-κB reporter gene assays. Results and discussion: As a result, seven compounds were isolated and identified, in which three of them were reported for the first time from genus Lantana. For the TNF-α ELISA assay, compound 1 significantly reduced the level of TNF-α (83.5 pg/mL), while compounds 2 and 3 showed moderate inhibition to TNF-α level (144.7 ± 7.43 and146.2 ± 5.27 pg/mL respectively). In addition, the NF-κB reporter gene assay revealed that the tested compounds (1-2) inhibited the relative NF-κB activity which was induced by TNF-α (0.41 ± 0.01 and 0.47 ± 0.01, respectively). Staursporine was used as a positive control in both assays. Conclusion: Linalool glycosides isolated from flowers of L. montevidensis exhibited significant anti-inflammatory activity by reducing the TNF-α level and inhibition of NF-κB pathway.","PeriodicalId":18897,"journal":{"name":"Natural products chemistry & research","volume":"13 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural products chemistry & research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35248/2329-6836.20.8.375","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Background and objective: Inflammation has been studied for thousands of years in an effort to mitigate its negative effects on the body. Analgesic and anti-inflammatory drugs were the primary concern in monoterpenes. Monoterpenes have been recognized for their ability to suppress inflammatory process and modulate the vital chemical mediators of inflammation, such as pro-inflammatory and anti-inflammatory cytokines. This study aimed to isolate the secondary metabolites of Lantana montevidensis (Verbenaceae) flowers and evaluate their in vitro antiinflammatory activity. Material and methods: Anti-inflammatory activity was done using TNF-α ELISA and NF-κB reporter gene assays. Results and discussion: As a result, seven compounds were isolated and identified, in which three of them were reported for the first time from genus Lantana. For the TNF-α ELISA assay, compound 1 significantly reduced the level of TNF-α (83.5 pg/mL), while compounds 2 and 3 showed moderate inhibition to TNF-α level (144.7 ± 7.43 and146.2 ± 5.27 pg/mL respectively). In addition, the NF-κB reporter gene assay revealed that the tested compounds (1-2) inhibited the relative NF-κB activity which was induced by TNF-α (0.41 ± 0.01 and 0.47 ± 0.01, respectively). Staursporine was used as a positive control in both assays. Conclusion: Linalool glycosides isolated from flowers of L. montevidensis exhibited significant anti-inflammatory activity by reducing the TNF-α level and inhibition of NF-κB pathway.