Effects of Xiao-Ban-Xia-Tang on cisplatin and 1-PBG induced pica and gut microbiota in rats

Journal of Holistic Integrative Pharmacy Pub Date : 2022-06-01 DOI:10.1016/S2707-3688(23)00053-5

Yanhong YANG , Xiaodi FENG , Siqi CHEN , Qi MENG , Qianqian CHENG , Ke NIE

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Abstract

The effects of Xiao-Ban-Xia-Tang (XBXT) formula on cisplatin and 1-PBG induced emesis and gut microbiota were studied in this experiment. Cisplatin and 1-PBG induced pica rat models were established, the amount of kaolin intake was observed, and the effects of XBXT and ondansetron on the gut microbiota were studied by 16S rDNA gene analysis. The results showed that XBXT and ondansetron could ameliorate the acute and delayed pica induced by cisplatin and 1-PBG. XBXT decreased Firmicutes in the cisplatin treated rats. Ondansetron decreased the alpha diversity of the gut microbiota, and it decreased Firmicutes and increased Bacteroidetes in the cisplatin and 1-PBG treated rats. XBXT was as effective as ondansetron in the treatment of pica, while ondansetron was more likely to cause gut microbiota dysbiosis than XBXT. Our study provided new avenues for the roles and mechanisms of XBXT on the prevention and treatment of CINV.

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消斑下汤对顺铂、1-PBG诱导的异食癖大鼠及肠道菌群的影响

本试验研究消斑下汤对顺铂和1-PBG诱导呕吐及肠道菌群的影响。建立顺铂和1-PBG诱导异食癖大鼠模型，观察高土摄取量，并通过16S rDNA基因分析研究XBXT和昂丹司琼对肠道菌群的影响。结果表明，XBXT和昂丹司琼能改善顺铂和1-PBG诱导的急性和迟发性异食癖。XBXT降低顺铂治疗大鼠厚壁菌群。在顺铂和1-PBG治疗的大鼠中，昂丹司琼降低了肠道微生物群的α多样性，减少了厚壁菌门，增加了拟杆菌门。XBXT治疗异食症的效果与昂丹司琼相当，而昂丹司琼比XBXT更容易引起肠道菌群失调。本研究为XBXT在预防和治疗CINV中的作用和机制提供了新的途径。

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Journal of Holistic Integrative Pharmacy

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