Use of Oral Contraceptive Pills in the Treatment of the Endometrial Polyps Smaller than 1.5 cm

M. Barati, L. Zarei, N. Shahbazian, S. Masihi, Maryam Baghaei Nezhad, F. Moramezi
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Abstract

The study aimed at the evaluation of the impacts of oral contraceptive pills on the treatment of the endometrial polyps smaller than 1.5 cm. In this study, fifty women childbearing ages between 20-40 years referred to the gynecological and midwifery section of the hospital, who had the asymptomatic endometrial polyps smaller than 1.5 cm. They were randomly divided into two groups "control" and "case" individually 25 members. The group case, were treated for three months with oral contraceptive pills. Women were examined in sonography before and after taking pills in order to measure the polyp size. Almost 24% of the group case responded to treatment, 32% size reduction and 44% remained with no change in size. While, in the control group there was 28% size reduction, 37% neutral and 35% encountered increase in size was unchanged. The average size of endometrial polyps in the group control did not take statistical significance difference before and later than treatment (9.5 vs. 8.6 mm, p = 0.297). However, the size of the polyp in the group case had significant statistical difference before and after the treatment (9.5 vs. 6.3 mm, p<0.05). Use of oral contraceptive pills in the treatment of endometrial polyps is low cost and non-invasive compared with such surgical procedures as curettage and hysteroscopy. Therefore, in this regard, further studies are recommended.
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口服避孕药在治疗小于1.5 cm子宫内膜息肉中的应用
本研究旨在评价口服避孕药治疗小于1.5 cm的子宫内膜息肉的效果。在这项研究中,50名育龄在20-40岁之间的妇女在医院妇科和助产士科就诊,她们患有小于1.5厘米的无症状子宫内膜息肉。他们被随机分为“对照组”和“实验组”两组,每组25人。组病例均口服避孕药治疗3个月。在服药前后分别进行超声检查,以测量息肉的大小。几乎24%的组病例对治疗有反应,32%的大小减少,44%的大小没有变化。而在对照组中,有28%的大小减小,37%的大小不变,35%的大小不变。对照组子宫内膜息肉平均大小与治疗前后比较,差异无统计学意义(9.5 mm vs 8.6 mm, p = 0.297)。而组病例息肉大小治疗前后差异有统计学意义(9.5 mm vs 6.3 mm, p<0.05)。使用口服避孕药治疗子宫内膜息肉,与刮除和宫腔镜等外科手术相比,成本低,无创。因此,在这方面,建议进行进一步的研究。
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