Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide

Journal of Faculty Pharmacy of Istanbul University Pub Date : 2015-01-01 DOI:10.16883/JFPIU.58800

N. Güzeldemirci, Dilek Şatana, Ö. Küçükbasmacı

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引用次数: 1

Abstract

Abstract: In this study, some novel N2-arylidene/cycloalkylidene-(6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazides (2a-d) were synthesized from (6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide (1). The newly synthesized compounds were characterized by IR, 1H NMR, mass and elemental analysis. Their antibacterial and antifungal activities were evaluated against S. aureus ATCC 29213, P. aeruginosa ATCC 27853, E. coli ATCC 25922, C. albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, T. mentagrophytes var. erinacei NCPF 375, M. gypseum NCPF 580 and T. tonsurans NCPF 245. N2-Cyclohexylidene-(6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide (2c) and N2-(3-methylcyclohexylidene)-(6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide (2d) showed the highest antibacterial activity. Particularly 2c showed the highest antifungal activity against tested fungi. Key words: Imidazo[2,1-b]thiazole, arylidene/cycloalkylidenehydrazides, antibacterial activity, antifungal activity

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6-(4-硝基苯基)咪唑[2,1-b]噻唑-3-乙酸肼新腙衍生物的合成及抗菌评价

摘要:以(6-(4-硝基苯基)咪唑[2,1-b]噻唑-3-基)乙酸肼(1)为原料，合成了一些新型的n2 -芳基/环烷基基-(6-(4-硝基苯基)咪唑[2,1-b]噻唑-3-基)乙酸肼(2a-d)。通过IR、1H NMR、质量和元素分析对新合成的化合物进行了表征。对金黄色葡萄球菌ATCC 29213、铜绿假单胞菌ATCC 27853、大肠杆菌ATCC 25922、白色假单胞菌ATCC 10231、假单胞菌ATCC 22019、克鲁氏假单胞菌ATCC 6258、红绿单胞菌NCPF 375、石膏假单胞菌NCPF 580和T. tonsurans NCPF 245的抑菌活性进行了研究。N2-(3-甲基环己基)-(6-(4-硝基苯基)咪唑[2,1-b]噻唑-3-基)乙酸肼(2c)和N2-(3-甲基环己基)-(6-(4-硝基苯基)咪唑[2,1-b]噻唑-3-基)乙酸肼(2d)抗菌活性最高。其中2c对被试真菌的抗真菌活性最高。关键词:咪唑[2,1-b]噻唑，芳烯/环烷基烯酰肼，抗菌活性，抗真菌活性

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Journal of Faculty Pharmacy of Istanbul University

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