New medication for treatment of radiation-thermal burns

Abstract

The paper provides the procedure of preparation and application of the developed remedy for treatment of combined radiation-thermal skin injuries, caused by excessive heat and radiation. The developed medication, ointment, contains biologically active substances, such as streptoform, dimexide and a vaseline as the ointment base. Optimum ratio of ointment components was determined experimentally. The medication efficacy was studied in experiments on white rats of both sexes, with average mass of 180-200 grams. The animals were divided in groups according to the analogy principle. Radiation induced injury of skin were simulated with the use of the gamma ray unit “Puma” with absorbed dose of 7.0 Gy, exposure dose rate of 5.9 R/min (8.5х10-2 A/kg). The irradiated animals were subjected to a thermal skin damage (burn) by placing brass plate heated to 180oC immediately after the animals irradiation completion. The placed plate was hold to the hair-free skin area on the upper third of the thigh for several seconds. By degree of skin and subcutaneous tissues the thermal damage degree is identical to the degree of IIIB. Immediately after radiation exposure and introduction of thermal damages the experimental ointment samples were spread on the injury surface with the gauze sponge or plastic spreader once a day. The developed remedy was found to be effective. The mass fraction (wt%) of the burn-releaf ointment components are the following: dimexide 19-20 wt%; streptoform 30-35 wt%, vaseline 45-52 wt%.