Pyrethrin from Tanacetum cineriifoliun as repellent against mosquitoes

International Current Pharmaceutical Journal Pub Date : 2013-09-14 DOI:10.3329/ICPJ.V2I10.16411

P. Amrutha, B. S. Priya, S. Lakshmanasenthil, A. Jenifer, L. Pillai, G. Suja, T. Vinothkumar

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引用次数: 6

Abstract

The present study is conducted to find the efficacy of plant extracts to act as mosquito repellents. Initially, the larvicidal activity of the extracts and the toxicity study was conducted. From the results, the extracts with maximum larvicidal activity and the minimum toxicity were used for the further analysis. The least toxicity was observed with the ethanol extracts of Lantana camara , Tagetes erecta and Tanacetum cineriifolium . The Lanatana camara and Tanacetum cineriifolium showed the maximum larvicidal activity. The DNA sugar damage assay is performed and read at 532 nm. The hemolytic activity of the extract is conducted and the results indicate that the extracts showed no hemolytic activity at the concentration of 100 and 200mg/L. Only the flower extracts of Tagaetes erecta, Lantana camara and Tanacetum cineriifolium showed moderate hemolytic activity at 500 and 1000 mg/L. Finally, the HPLC analysis of the extracts showed that the ethanol extracts of Lantana camara and Tanacetum cineriifloium revealed the presence of marker compound. Therefore the ethanol extracts of Lantana camara and Tanacetum cineriifolium were taken up for the membrane stabilization assay. The skin irritation potential of the cream prepared using the ethanol extract of Tanacetum cineriifolium was analysed, the cream showed no irritation. DOI: http://dx.doi.org/10.3329/icpj.v2i10.16411 International Current Pharmaceutical Journal, September 2013, 2(10): 170-176

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除虫菊酯的驱蚊作用

本研究旨在研究植物提取物的驱蚊作用。初步进行了提取物的杀幼虫活性和毒性研究。从实验结果中筛选出杀虫活性最高、毒性最低的提取物进行进一步分析。山楂叶、万寿菊和银杏叶乙醇提取物的毒性最小。杀幼虫活性最高的是小绒猴和灰绒猴。DNA糖损伤实验在532 nm处进行并读取。对提取物进行溶血活性测定，结果表明，在浓度为100和200mg/L时，提取物无溶血活性。在500和1000 mg/L浓度下，只有万寿菊(Tagaetes erececta)、山楂花(Lantana camara)和柽柳(Tanacetum cineriolium)的花提取物具有中等溶血活性。最后，对提取物进行高效液相色谱分析，结果表明，大叶烟叶和灰叶烟叶乙醇提取物中存在标记化合物。因此，本文以大叶烟叶和灰叶烟叶的乙醇提取物为研究对象进行了膜稳定实验。对丹参乙醇提取物制备的乳膏的皮肤刺激电位进行了分析，乳膏无刺激性。DOI: http://dx.doi.org/10.3329/icpj.v2i10.16411国际现代医药杂志，2013年9月，2(10):170-176

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International Current Pharmaceutical Journal

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