Formulation and investigation of crushed puffed rice-chitosan-HPMC based polymeric blends as carrier for sustained stomach specific drug delivery of piroxicam using 3(2) Taguchi mathematical design studies

Shashank Soni, Veerma Ram, A. Verma
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引用次数: 6

Abstract

In the present experimental investigation an attempt has been made to assess the utility of Crushed Puffed Rice (CPR)-High Molecular Weight Chitosan (HMWCH)-Hydroxypropyl Methylcellulose K15M (HPMC K15M) as a polymeric carrier for the sustained stomach delivery of Piroxicam (PRX). A total of nine formulations were prepared by using 3 (2) Taguchi factorial design, physically blending drug and polymer(s) followed by encapsulation into hard gelatin capsules size 1. The prepared capsules were evaluated for various performance such as weight variation, drug contents, in vitro buoyancy and drug release in 0.1 M HCl. The effect of drug loading on in vitro performance of the formulations was also determined. Crushed puffed rice (CPR) remained buoyant for up to average time span of 06 hr as an unwetted irregular mass in 0.1 M HCl. However, when combined with HMWCH or HPMC K15M or HPMC K15M + HMWCH a low -density cylindrical raft type hydrogel was formed which remained buoyant for up to 12 hr and released up to 99% drug in a sustained manner from 8 to 12 hr following zero order release kinetics. It was also observed that drug release from drug + CPR matrices followed Fickian mechanism. Combination of CPR + HMWCH or HMWCH + HPMC K15M also follows Fickian mechanism. Obtained data from the research work suggests that CPR in combination with HMWCH or HPMC K15M or HPMC has sufficient potential to be used as a carrier for stomach specific delivery of gastric irritant drug like PRX.
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用3(2)田口数学设计研究了膨化大米-壳聚糖- hpmc基聚合物共混物作为吡罗昔康持续胃特异性给药载体的配方和研究
在本实验研究中,我们试图评估粉碎膨化大米(CPR)-高分子量壳聚糖(HMWCH)-羟丙基甲基纤维素K15M (HPMC K15M)作为吡罗西康(PRX)持续胃递送的聚合物载体的效用。采用3(2)田口析因设计,将药物与聚合物物理混合,然后包封成尺寸为1的硬明胶胶囊,共制备了9种制剂。对制备的胶囊进行了重量变化、药物含量、体外浮力和在0.1 M HCl中的药物释放等性能评价。测定了载药量对制剂体外性能的影响。碾碎的膨化大米(CPR)在0.1 M HCl中以未湿的不规则质量体的形式保持浮力,平均时间长达06小时。然而,当与HMWCH或HPMC K15M或HPMC K15M + HMWCH结合时,形成低密度圆柱形筏型水凝胶,其保持浮力长达12小时,并在8至12小时内持续释放高达99%的药物,遵循零级释放动力学。同时观察到药物+ CPR基质的药物释放遵循菲克机制。CPR + HMWCH或HMWCH + HPMC K15M的组合也遵循Fickian机制。从研究工作中获得的数据表明,CPR联合HMWCH或HPMC K15M或HPMC有足够的潜力作为胃特异性递送PRX等胃刺激性药物的载体。
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