Effects of Liupao Tea Ingredients on Intestinal Microflora in Collagen Induced Arthritis DBA/1 Mice

Abstract

To investigate the effect of ingredients from Liupao tea on the gut microbiota structure of collagen induced arthritis models, rheumatoid arthritis model was established by injecting bovine type II collagen into the tail of DBA/1 mice, and treated with Liupao tea extracts and gallic acid by gavage. Both Liupao tea and gallic acid can ameliorate intestinal microbiota disorder. Liupao tea increases the abundance of Alloprevotella, Muribaculaceae, and Alistipes in the intestine of a mouse model, while reducing the abundance of Colidextribacter, Lachnospiraceae_NK4A136_group, Lachnoclo-stridium, and Lactobacillus, with gallic acid increasing the abundance of Muribaculaceae, Clostri-dia_UCG-014 and Alloprevotella, reducing the abundance of Lachnospiraceae_NK4A136_group, Lachnospiraceae_UCG-006and Lachnoclostridium. Both of Liupao tea and gallic acid can certainly correct intestinal microbiota disorders. The ingredients of Liupao tea and gallic acid can significantly improve the structure of intestinal microbiota in mice with rheumatoid arthritis.