Thyroid Dysfunction in Epileptic Children and Association with Antiepileptic Drugs in Sudan

Reeham Abdoalhamid Osman Abobker, O. F. Idris, Murwan Khalid Sabahelkkier
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引用次数: 2

Abstract

There are limited and conflicting data about the effect of antiepileptic drugs on thyroid gland in children. The objective of this study to investigate the effects of TSH and thyroid hormone in children receiving the valproate, carbamazepine. Cross sectional case control study was conducted at omdurman children hospital which is general pediatrics hospital with many referred clinics including neurology clinic, ahmed gasam children hospital is general pediatrics hospital, Abraham malak hospital during the period from March to May 2015. In this study 100 children Sudanese patient have epilepsy and receiving, antiepileptic drugs for at least 1 years and diagnosed as epileptic based on EEG (case) and 50 sudanese children as (control). The study showed that children use carbamazepine drugs there was significant increase in mean concentration of TSH comparison with control groups with p-value 0.000 and significant decrease in mean concentration of T4 comparison with control groups with p-value 0.000 and significant minor decrease of T3 comparison with control groups with p-value 0.002 , and children use valporate group showed was significant increase in mean concentration of TSH comparison with control groups with p-value 0.000 and significant decrease in mean concentration of T4 comparison with control groups with p-value 0.000 and significant normal of T3 comparison with control groups with p-value 0.000. Our data suggest that all antiepileptic drugs studied had varying degrees of deleterious effects on thyroid function.
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苏丹癫痫儿童甲状腺功能障碍及其与抗癫痫药物的关系
关于抗癫痫药物对儿童甲状腺的影响的数据有限且相互矛盾。本研究的目的是探讨接受丙戊酸、卡马西平治疗的儿童TSH和甲状腺激素的影响。横断面病例对照研究于2015年3月至5月期间在omdurman儿童医院进行,该医院是综合儿科医院,有许多转诊诊所,包括神经病学诊所,ahmed gasam儿童医院是综合儿科医院,Abraham malak医院。本研究以100例苏丹儿童癫痫患者为例,经脑电图诊断为癫痫,服用抗癫痫药物至少1年(例),50例苏丹儿童为对照组。研究显示,卡马西平患儿TSH平均浓度较对照组显著升高(p值0.000),T4平均浓度较对照组显著降低(p值0.000),T3显著降低(p值0.002);与p值为0.000的对照组相比,TSH平均浓度显著升高;与p值为0.000的对照组相比,T4平均浓度显著降低;与p值为0.000的对照组相比,T3水平显著正常。我们的数据表明,所有研究的抗癫痫药物对甲状腺功能有不同程度的有害影响。
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