Sugar Palm Fruits (Arenga pinnata) as Potential Analgesics and Anti-Inflammatory Agent

MCBS Molecular and Cellular Biomedical Sciences Pub Date : 2019-09-01 DOI:10.21705/mcbs.v3i2.63

E. Sovia, Dian Anggraeny

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引用次数: 9

Abstract

Background: Sugar palm fruit (Arenga pinnata) is used for osteoarthritis empirically. It also has antioxidant activity and showed inhibition to lipoxygenase activity. The study about analgesic and anti-inflammatory activities of sugar palm fruit is still limited, this study was initiated to explore analgesic and anti-inflammatory effects of sugar palm fruit ethanol extract (SFEE).Materials and Methods: Acetic acid induced writhing was performed for screening analgesic activity, meanwhile antiinflammatory activity was tested against rat paw edema. Acute toxicity and phytochemical screening were also investigated.Results: The results of phytochemical screening revealed that flavonoids, alkaloids and quinones were present in SFEE. SFEE 50 and 100 mg/kg have analgesic effect and show the anti-oedematogenic effect against paw edema induced by carrageenan. SFEE could significantly decrease the neutrophils numbers as compared to the carrageenan-treated group. Neutrophil activation has been shown to contribute to tissue inflammation and damage.Conclusion: SFEE have analgetic and anti-inflammatory activity.Keywords: Arenga pinnata, analgesic, anti-inflammatory, acute toxicity

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糖棕榈果实(Arenga pinnata)作为潜在的镇痛和抗炎剂

背景:糖棕榈果实(Arenga pinnata)用于治疗骨关节炎的经验。它还具有抗氧化活性和抑制脂氧合酶活性。关于糖棕榈果的镇痛和抗炎作用的研究仍然有限，本研究旨在探讨糖棕榈果乙醇提取物(SFEE)的镇痛和抗炎作用。材料与方法:采用醋酸扭体法筛选大鼠足部镇痛活性，同时测定大鼠足部水肿的抗炎活性。急性毒性和植物化学筛选也进行了研究。结果:植物化学筛选结果显示，SFEE中含有黄酮类、生物碱类和醌类化合物。sfe50和100 mg/kg对卡拉胶所致足跖水肿均有镇痛作用和抗致肿作用。与卡拉胶处理组相比，SFEE可显著降低中性粒细胞数量。中性粒细胞活化已被证明有助于组织炎症和损伤。结论:SFEE具有镇痛、抗炎作用。关键词:桄榔子;镇痛;抗炎

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MCBS Molecular and Cellular Biomedical Sciences

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20 weeks