CHARACTERIZATION AND SOLUBILITY ENHANCEMENT OF GLICLAZIDE SOLID DISPERSION USING PVP-K30 & K -90

Abstract

The purpose of this study was to design Polyvinylpyrrolidone (PVP) based solid dispersions bearing gliclazide. Polyvinylpyrrolidone (PVP K-30 and K-90) based solid dispersions containing the drug in different mass ratio i.e. 1:1, 1:3, 1:5 and 1:7 were prepared using fusion method. The prepared solid dispersions were characterized for their drug content, phase solubility studies, fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry, x-ray diffraction, and in-vitro dissolution studies. All the formulations showed marked improvement in the solubility and dissolution rate of drug from solid dispersion is due to decrease in crystallinity of drug and additives. It was concluded that prepared solid dispersion of the gliclazide with Polyvinylpyrrolidone may improved the solubility and dissolution rate of the drug.