Bladder Paraganglioma: Report of Two Cases and A Literature Review

Abstract

Objective: We report two incidental cases of bladder paraganglioma and a review of the literature published to date. Methods: Medline was searched for the last 10 years for the terms "paraganglioma" and "urinary" and "bladder". Results: Bladder paraganglioma (BP) is extremely rare. It represents 10% of all paragangliomas and concerns less than 0.06% of bladder tumors. Often discovered by chance, it can nevertheless be symptomatic, particularly during micturition. The most common symptoms are hematuria, hypertension and headache. About 14% of these tumors are malignant and radio-chemically resistant. Surgery is therefore the cornerstone of treatment. We recommend, cystoscopy, partial cystectomy and regular follow-up based on regular cystoscopy and imaging. Their rarity explains why, at present, there are no recommendations for treatment and monitoring. However, their risk of malignancy recurrence and metastasis requires regular and long-term follow-up. Conclusions: Bladder paragangliomas are rare tumors. Treatment should be based on partial cystectomy and their follow-up should be regular.