In vivo anti-diabetic effects of aqueous leaf extracts of Rhoicissus tridentata in alloxan induced diabetic mice

Journal of Developing Drugs Pub Date : 2015-06-08 DOI:10.4172/2329-6631.1000131

M. J. Mukundi, N. E. Mwaniki, N. M. Piero, Njagi J Murugi, Agyirifo S Daniel, Gathumbi K Peter, Muchugi N Alice

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引用次数: 21

Abstract

The drawbacks associated with conventional anti-diabetic agents have largely stimulated desire for alternative and complementary anti-diabetic agents, majority of which are plant-derived. The medicinal plant, Rhoicissus tridentata has been used extensively in traditional medical practice against various ailments. However, its ethno medicinal use against diabetes mellitus has not been scientifically evaluated and validated. This study was, therefore, designed to evaluate the anti-diabetic potential of aqueous leaf extracts of Rhoicissus tridentata in alloxan induced diabetic mice. As the results show, the aqueous leaf extracts of Rhoicissus tridentata showed anti-diabetic activity. The intraperitoneal route of herbal extract administration was found to be more effective than the oral route. Further, qualitative and quantitative phytochemical screening of aqueous leaf extracts of Rhoicissus tridentata indicated the presence of phenols, alkaloids, flavonoids, tannins and saponins. However, cardiac glycosides and phylobatanins were not detected.

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三叉荆叶水提物对四氧嘧啶诱导的糖尿病小鼠的体内抗糖尿病作用

传统抗糖尿病药物的缺点在很大程度上刺激了对替代和补充抗糖尿病药物的需求，其中大多数是植物来源的。药用植物三叉戟在传统医学实践中被广泛用于治疗各种疾病。然而，其对糖尿病的民族药用作用尚未得到科学的评价和验证。因此，本研究旨在评价三叉戟叶水提物对四氧嘧啶诱导的糖尿病小鼠的抗糖尿病作用。结果表明，三叉戟叶水提物具有抗糖尿病活性。研究发现，中药提取物腹腔给药比口服给药更有效。此外，对三叉红叶水提物进行了定性和定量的植物化学筛选，发现其中含有酚类、生物碱、黄酮类、单宁和皂苷。但未检测到心糖苷和藻蓝蛋白。

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Journal of Developing Drugs

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