Anticandidal Activity of Polymorphonuclear Leukocytes and Serum Transferrin in Tumor-Implanted Mice

Abstract

Meth-A fibrosarcoma-implanted mice were examined for protective activity to lethal Candida albicans infection. The number of peripheral blood polymorphonuclear leukocytes (PMNs) was markedly increased in the mice, and their candidacidal function was also activated. The growth of C. albicans invitro was inhibited by the addition of serum from Meth-A-implanted mice. This activity was inhibitedby the addition of an inhibitor of transferrin, ferric sulphate. These findings indicated that C. albicans cells were efficiently eliminated by the activated PMNs and that the elimination was increased by the serum transferrin in Meth-A-implanted mice. leukocytes, Transferrin,