Malignant fibrous histiocytoma of the jaws: A report of 3 cases

Abstract

Malignant fibrous histiocytoma (MFH) of the jaws aggressively invades adjacent tissues with a high local recurrence rate. Although radical excision with adequate tumor-free margins is essential, from the anatomical point of view wide resection is often difficult in the head and neck region. We reported 3 cases of MFH arising in the jaws. All three cases were males with 36–51 years old. One disease occurred in the mandible and the others in the maxilla. All cases underwent wide local excision and followed by adjuvant chemotherapy of 2 cycles consisting ifosfamide (IFO), cisplatin (CDDP) and doxorubicin (DOX). In 2 cases, neither tumor recurrence nor metastasis developed at follow-up of 78 months and 70 months. In one case, the patient died from tumor recurrence at follow-up of 2 months. The effects of combined treatment with surgery and adjuvant chemotherapy for MFH of jaws will be assessed by further follow-up.