Asian Journal of Oral and Maxillofacial Surgery最新文献

Spindle cell carcinoma is a rare malignant tumour that shows biphasic proliferation of squamous cell carcinoma components and sarcomatoid components of spindle-shaped cells in the same tissue. In addition, cases that a malignant tumour of the head and neck region metastasizes to the thyroid gland are extremely rare. We report an extremely rare case that spindle cell carcinoma of the tongue metastasized to the thyroid gland. A 59-year-old female presented with a polypoid mass in the right margin of the tongue. Based on histopathological diagnosis of spindle cell carcinoma of clinical staging II, a partial glossectomy was performed. Thyroid mass appeared at 5 months after the surgery. She was diagnosis with thyroid gland cancer and a total thyroidectomy was performed. A histopathological diagnosis revealed thyroid gland metastasis. However, a thyroid tumour recurred in the neck at 4 months after the thyroid surgery. The tumour was untreatable, and the patient expired 13 months after the primary resection.

Bisphosphonate (BP) is used widely for the treatment of osteoporosis and other diseases. BP-related osteonecrosis of the jaw (BRONJ) has been recognized recently as a result of the increased use of BP to prevent bone fracture and osteoporosis in elderly people. Much attention has also been given to patients with dental diseases who are administered BP, and ulcers with osteonecrosis are also noted in conjunction with BRONJ [1], [2]. However, oral mucosal ulcers on the tongue or cheek without BRONJ are not common. To our knowledge, only 7 cases of mucosal ulceration have been identified in previous reports published in English and Japanese [3], [4], [5], [6], [7], [8], [9]. Therefore the clinical behavior, treatment and outcome of ulcers are not well documented. In this report, we describe a case of ulcers occurring on the tongue without BRONJ, and discuss the clinical aspects of BP-induced ulcers, including their treatment and potential cause.

Mulvihill–Smith syndrome (MSS) is a very rare disease that is characterized by short stature, a senile face with an under-developed lower half, microcephaly, multiple pigmented nevi, immunodeficiency, hearing loss, and high-pitched voice. We report on the oral manifestations and management of a 27-year-old woman with this syndrome, who underwent removal of a mandibular cyst and partial resection of the tongue.

Mucosa-associated lymphoid tissue (MALT) lymphoma arising in the sublingual gland of the oral cavity is very rare. We present here a single case of MALT lymphoma arising from the sublingual gland of a 64-year-old man. His first symptom was swelling on the left side of the floor of the mouth. On the basis of the results of imaging studies, a salivary gland tumor was suspected. The tumor was dissected surgically and microscopically, revealing dense atypical lymphoid cell infiltration with severe destruction of adjacent normal salivary glands. Immunohistochemical staining of atypical lymphoid cells was positive for CD20 and CD79a. Ki-67 positive cells were localized to scattered transformed large cells. As a result, the tumor was diagnosed as a primary sublingual gland marginal zone B cell lymphoma of MALT type.

Malignant transformation of pleomorphic adenoma is rare. Herein, we present a rare case of invasive carcinoma ex pleomorphic adenoma in the submandibular gland and describe our experience with the clinical presentation, surgical management and outcomes of patients with this pathology.

Restoring shape and functions in patients with total mandibular defect is difficult. We report the use of a fibular bone graft for successful total mandibular reconstruction of a patient with traumatic injury to the mandible. A 56-year-old man experienced a work-related injury to the maxillo-facial region and underwent total mandibular resection. Five years later, he remains satisfied with his facial configuration and has minimal dysfunction in daily activities, including speaking, swallowing, and eating. Evaluation of the functional adaptation of his facial muscles by electromyography (EMG) showed that his orbicularis oris muscle may have compensated for masticatory muscle dysfunctions during mouth opening and swallowing.

Burning mouth syndrome a chronic oro-facial pain syndrome that affects many adults world over remains poorly understood and is one of the most important dental issues facing dentists worldwide. It is associated with many oral and systemic conditions. The treatment frequently involves medications and dentists should be able to evaluate, diagnose and properly manage these patients.

Molecular targeting therapy has recently received attention owing to its high specificity for cancer cells; numerous researchers have been working to identify novel target molecules. In this study, we attempted to identify new targets through cell-based screening with inhibitor panel kits. The growth-inhibitory effects of inhibitors from the Screening Committee of Anticancer Drugs inhibitor kits, which contain 173 chemical inhibitors, were evaluated in oral squamous-cell carcinoma (OSCC) cell lines. Some of the inhibitors strongly suppressed the proliferation of OSCC cells. Of these inhibitors, we chose JSI-124, a specific inhibitor of STAT3, to investigate further. JSI-124 significantly inhibited the growth of OSCC cell lines and then induced DNA fragmentation, poly (ADP-ribose) polymerase cleavage, and caspase 3 activation in a dose-dependent manner. Treatment with JSI-124 resulted in a decrease of phosphorylated STAT3 and a downregulated expression of survivin, a downstream molecule of the STAT3 signaling cascade. Our data suggest that inhibition of STAT3 signaling by JSI-124 might be promising as a molecular therapy strategy against OSCC.

A 45-year-old Japanese woman presented complaining of swelling of the right mandible. Initial histopathological diagnosis was cemental dysplasia. Because of rapid enlargement of the lesion, surgical resection was performed. The post-surgical second histopathological diagnosis was osteosarcoma. In spite of additional treatment with radiotherapy and chemotherapy, the patient died 32 months after the initial visit. Autopsy revealed osteosarcoma with metastases infiltrating of a number of organs, including the lungs, heart, and vertebrae.