Search for active candidates in a range of flavonoids regarding SARS-CoV-2 by the method of molecular docking

S. V. Pechinskii, E. Oganesyan, A. G. Kuregyan
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引用次数: 1

Abstract

Molecular docking is a convenient and cost-effective tool for targeted screening of biologically active structures. This method makes it possible to reveal the relationship between structure and activity, as well as to search for new active compounds. Due to the fact that the antiviral activity of flavonoids and their derivatives has been shown experimentally and clinically, the study of their antiviral activity against SARS-CoV-2 is a promising study. In an in silico experiment, the possibility of binding 20 flavonoid ligands and the main protease SARS-CoV-2 was studied. The structural features of flavone and flavanone derivatives have been determined, which determine their ability to block the main protease of the SARS-CoV-2 virus. Structures of eight new candidates that bind the main protease SARS-CoV-2, which have the prospect of synthesis and further pharmacological research, have been proposed.
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通过分子对接的方法在一系列针对SARS-CoV-2的类黄酮中寻找活性候选物
分子对接是一种方便、经济的靶向筛选生物活性结构的工具。这种方法可以揭示结构与活性之间的关系,也可以寻找新的活性化合物。由于黄酮类化合物及其衍生物的抗病毒活性已被实验和临床证明,因此研究其对SARS-CoV-2的抗病毒活性是一项有前景的研究。在硅实验中,研究了20种类黄酮配体与主要蛋白酶SARS-CoV-2结合的可能性。黄酮和黄酮衍生物的结构特征已经确定,这决定了它们阻断SARS-CoV-2病毒主要蛋白酶的能力。提出了8种结合主要蛋白酶SARS-CoV-2的新候选物的结构,这些候选物具有合成和进一步药理研究的前景。
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