Application Value of Serum Hcy, TLR4, and CRP in the Diagnosis of Cerebral Small Vessel Disease.

IF 0.2 4区艺术学 0 ARCHITECTURE Interiors-Design Architecture Culture Pub Date : 2022-04-23 eCollection Date: 2022-01-01 DOI:10.1155/2022/4025965

Peng Qu, Kaili Cheng, Qi Gao, Yan Li, Minghua Wang

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引用次数: 1

Abstract

Objective: To evaluate the application value of combined detection of serum homocysteine (Hcy), Toll-like receptor 4 (TLR4), and C-reactive protein (CRP) in the diagnosis of cerebral small vessel disease (CSVD).

Methods: 90 patients with CSVD admitted to our hospital within the past year were identified as the research subjects, and the patients with cognitive dysfunction were assigned to the experimental group, and those with normal cognitive function were assigned to the control group according to the evaluation of cognitive dysfunction by the Montreal Cognitive Assessment (MoCA), with 45 cases in each group.

Results: The experimental group obtained remarkably elevated Hcy levels than the control group (P < 0.05). The patient's cognitive dysfunction is mainly attributed to the impact of serum Hcy. TLR4 and Hcy were negatively correlated with MoCA scores (P > 0.05). In comparison with the control group, the experimental group had significantly higher levels of Hcy, serum CRP, and interleukin (IL)-6 (P < 0.05).

Conclusion: The combined detection of serum Hcy, TLR4, and CRP features a high clinical value in the diagnosis of CSVD, which contributes to the prevention and treatment of cognitive dysfunction in patients.

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血清 Hcy、TLR4 和 CRP 在诊断脑小血管疾病中的应用价值

目的评估联合检测血清同型半胱氨酸（Hcy）、Toll样受体4（TLR4）和C反应蛋白（CRP）在脑小血管病（CSVD）诊断中的应用价值。方法：以我院近一年内收治的90例CSVD患者为研究对象，根据蒙特利尔认知评估（MoCA）对认知功能障碍的评估结果，将认知功能障碍患者分为实验组，将认知功能正常者分为对照组，每组45例：实验组的 Hcy 水平明显高于对照组（P<0.05）。患者的认知功能障碍主要归因于血清 Hcy 的影响。TLR4 和 Hcy 与 MoCA 评分呈负相关（P > 0.05）。与对照组相比，实验组的 Hcy、血清 CRP 和白细胞介素（IL）-6 水平明显更高（P < 0.05）：结论：联合检测血清 Hcy、TLR4 和 CRP 在 CSVD 诊断中具有较高的临床价值，有助于患者认知功能障碍的预防和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interiors-Design Architecture Culture ARCHITECTURE-

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