{"title":"Xylometazoline nasal spray solution: novel composition used for treatment of nasal congestion","authors":"Falgun Bhuva, L. Patel","doi":"10.15406/MOJDDT.2018.02.00054","DOIUrl":null,"url":null,"abstract":"The preliminary objective of the work is to develop the meter dose formulation of xylometazoline hydrochloride for enhanced effectiveness for nasal decongestion The factorial design was utilized for development of the formulation where sodium cholate X and Polyethyleneglycol concentration X were independent factors The optimized formulation composition consisted of g sodium cholate and ml Polyethyleneglycol independent varibales The formulation was evaluated for solution parameters like assay pH viscosity diffusion sterility content uniformity pump delivery spray pattern and weight loss The percentage diffusion and viscosity was observed plusmn and plusmn centipoise respectively The meter dose nasal formulation provides alternative option for treatment of nasal decongestion which showed comparable results to marketed formulation","PeriodicalId":18704,"journal":{"name":"MOJ Drug Design Development & Therapy","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"MOJ Drug Design Development & Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/MOJDDT.2018.02.00054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The preliminary objective of the work is to develop the meter dose formulation of xylometazoline hydrochloride for enhanced effectiveness for nasal decongestion The factorial design was utilized for development of the formulation where sodium cholate X and Polyethyleneglycol concentration X were independent factors The optimized formulation composition consisted of g sodium cholate and ml Polyethyleneglycol independent varibales The formulation was evaluated for solution parameters like assay pH viscosity diffusion sterility content uniformity pump delivery spray pattern and weight loss The percentage diffusion and viscosity was observed plusmn and plusmn centipoise respectively The meter dose nasal formulation provides alternative option for treatment of nasal decongestion which showed comparable results to marketed formulation
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