{"title":"Experimental Evaluation of the Effectiveness and Safety of a New Propandic Acid Derivative Exhibiting Cardiotropic Action","authors":"D. Ivkin, A. A. Karpov","doi":"10.33647/2074-5982-18-3-109-112","DOIUrl":null,"url":null,"abstract":"An entire cycle of preclinical studies of 4-[(3-ethoxy-3-oxopropanoyl)amino]benzoic acid (etmaben) exhibiting cardiotropic action was carried out. Its potential action mechanism and pharmacological effects, general toxic effects in acute and chronic experiments, specific types of toxicity (allergenicity, immunotoxicity, reproductive toxicity, mutagenicity), and pharmacokinetics were studied. The drug was found to have a pronounced cardiotropic effect and a positive safety profile, which justifies the launch of phase I clinical trials.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"34 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal Biomed","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33647/2074-5982-18-3-109-112","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
An entire cycle of preclinical studies of 4-[(3-ethoxy-3-oxopropanoyl)amino]benzoic acid (etmaben) exhibiting cardiotropic action was carried out. Its potential action mechanism and pharmacological effects, general toxic effects in acute and chronic experiments, specific types of toxicity (allergenicity, immunotoxicity, reproductive toxicity, mutagenicity), and pharmacokinetics were studied. The drug was found to have a pronounced cardiotropic effect and a positive safety profile, which justifies the launch of phase I clinical trials.
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