A Prospective Observational Study: Phenytoin Pharmacokinetic Pattern in Cerebrovascular Accident and Head Trauma Patients in Warangal Population

Abstract

An phenytoin is commonly administered as prophylactic or treatment of epileptic episodes in acute brain injury due to head injury. The aim of the study is to evaluate PK pattern of phenytoin in patients with traumatic and non-traumatic brain injuries. This study was carried out in 30 adult head injury patients and who were administered with phenytoin for prophylaxis of post trauma seizures or treatment. Serum Phenytoin concentrations (Cp) were determined and were compared between CVA and HT patients. The Km and Vmax were significantly higher in HT patients. The Cp and the Cp/dose ratio were higher in the CVA patients significantly (P<0.05). APACHE П score was significantly lower than the baseline at the end of the study in each group of patients (P<0.05). Due to significant differences in Cp and PK parameters between HT and CVA patients, close attention must be paid to the PK behavior of phenytoin in the efforts to improve the patient’s outcome after a severe HT.