Pub Date : 2021-03-01DOI: 10.38111/IJAPB.20210701001
M. Awais, Salal Ahmad, M. Sajid, Waheed Nawaz, Muhammad Hamid, H. Nawaz
{"title":"Current Situation of Polio in Pakistan","authors":"M. Awais, Salal Ahmad, M. Sajid, Waheed Nawaz, Muhammad Hamid, H. Nawaz","doi":"10.38111/IJAPB.20210701001","DOIUrl":"https://doi.org/10.38111/IJAPB.20210701001","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"27 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91509755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.38111/ijapb.20200603005
D. Sandhya, G. Sowndarya, V. Swathi
{"title":"Stability indicating RP-HPLC Method for Simultaneous Estimation of Brinzolamide and Brimonidine in Pharmaceutical Dosage Forms","authors":"D. Sandhya, G. Sowndarya, V. Swathi","doi":"10.38111/ijapb.20200603005","DOIUrl":"https://doi.org/10.38111/ijapb.20200603005","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84846802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.38111/ijapb.20200602003
K. Sunkari, Pallavi Sunduru
A Lymphatic system is a network like system being extended all over the body and useful targets for efficient drug delivery for drugs having poor oral bioavailability in the intestine and less absorbed into systemic circulation because of drug degradation in GI tract. Lymphatic targeting is not only to treat various infections not limited to pathological conditions like human immunodeficiency virus and other diseases but also used in diagnosis of tumours along with metastasis. Moreover, lymph nodes are the site for faster spread source to tumours via metastasis. Under these circumstances, there is a need for effective delivery of drugs towards and through lymphatic networks. Nano based systems and lipid based systems have unique features as necessary candidates for lymphatic delivery. The review provides information about different routes, drug transport in the lymphatic system, physicochemical properties which give impact on lymphatic delivery.
{"title":"Lymphatic System: A Path for Drug Delivery","authors":"K. Sunkari, Pallavi Sunduru","doi":"10.38111/ijapb.20200602003","DOIUrl":"https://doi.org/10.38111/ijapb.20200602003","url":null,"abstract":"A Lymphatic system is a network like system being extended all over the body and useful targets for efficient drug delivery for drugs having poor oral bioavailability in the intestine and less absorbed into systemic circulation because of drug degradation in GI tract. Lymphatic targeting is not only to treat various infections not limited to pathological conditions like human immunodeficiency virus and other diseases but also used in diagnosis of tumours along with metastasis. Moreover, lymph nodes are the site for faster spread source to tumours via metastasis. Under these circumstances, there is a need for effective delivery of drugs towards and through lymphatic networks. Nano based systems and lipid based systems have unique features as necessary candidates for lymphatic delivery. The review provides information about different routes, drug transport in the lymphatic system, physicochemical properties which give impact on lymphatic delivery.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81643706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.38111/ijapb.20200601002
Amarnath Singadi, K. Venkateswarlu
{"title":"Synthesis of Piperonal based Dihydropyrimidinones and evaluation for possible Anticonvulsant and Antibacterial activities","authors":"Amarnath Singadi, K. Venkateswarlu","doi":"10.38111/ijapb.20200601002","DOIUrl":"https://doi.org/10.38111/ijapb.20200601002","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77305821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-16DOI: 10.38111/ijapb.20190504005
V. G, A. T, Sharvana Bhava B.S
Lichen planus hypertrophicus (LPH) is an ongoing provocative and resistant interceded illness that influences the skin, nails, hair, and mucous membranes. It is portrayed by polygonal, level bested, violaceous papules and plaques with overlying, reticulated, fine white scale (Wickham's striae), normally influencing dorsal hands, flexural wrists and lower arms, trunk, front lower legs and oral mucosa. Although there is an expansive clinical scope of LP indications, the skin and oral depression stay as the significant locales of involvement. The reason is obscure, yet it is believed to be the consequence of an immune system measure with an obscure introductory trigger. There is no fix, yet various drugs and techniques have been utilized in endeavors to control the indications.
{"title":"A Case Report: Lichen Planus Hypertrophicus","authors":"V. G, A. T, Sharvana Bhava B.S","doi":"10.38111/ijapb.20190504005","DOIUrl":"https://doi.org/10.38111/ijapb.20190504005","url":null,"abstract":"Lichen planus hypertrophicus (LPH) is an ongoing provocative and resistant interceded illness that influences the skin, nails, hair, and mucous membranes. It is portrayed by polygonal, level bested, violaceous papules and plaques with overlying, reticulated, fine white scale (Wickham's striae), normally influencing dorsal hands, flexural wrists and lower arms, trunk, front lower legs and oral mucosa. Although there is an expansive clinical scope of LP indications, the skin and oral depression stay as the significant locales of involvement. The reason is obscure, yet it is believed to be the consequence of an immune system measure with an obscure introductory trigger. There is no fix, yet various drugs and techniques have been utilized in endeavors to control the indications.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"47 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91043788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-16DOI: 10.38111/ijapb.20190504002
G. Durga Madhuri, A. Manga Devi, J. Swetha Srija, D. Narendra
{"title":"Evaluation of Antiurolithiatic Activity of Solidago virgaurea Against Ethylene Glycol Induced Renal Calculi in Rats","authors":"G. Durga Madhuri, A. Manga Devi, J. Swetha Srija, D. Narendra","doi":"10.38111/ijapb.20190504002","DOIUrl":"https://doi.org/10.38111/ijapb.20190504002","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78599111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-16DOI: 10.38111/ijapb.20190504004
T. N, G. Kalyani, Rinku Mathappan, R. Rajasekhar Reddy, D. Ravisankar Reddy
{"title":"A Demographic and Clinical Study on the Assessment of Dengue Fever Cases in a Tertiary Care Hospital Bangalore – A Prospective Study","authors":"T. N, G. Kalyani, Rinku Mathappan, R. Rajasekhar Reddy, D. Ravisankar Reddy","doi":"10.38111/ijapb.20190504004","DOIUrl":"https://doi.org/10.38111/ijapb.20190504004","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84312632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-16DOI: 10.38111/ijapb.20190504003
P. Ali, D. Singh, M. Raghavendra, K. Abbulu
Guillain-Barré syndrome (GBS), a rare neurological disorder which attack self-immune system especially peripheral nervous system (PNS)and its network of nerves located outside of the brain and spinal cord. GBS has a number of recognized subtypes that have differing clinical and pathophysiological features. Most of the incidence rates of GBS reported was between 1.1/100,000/year and 1.8/100,000/year with lower rates reported in children (less than 16 years) of 0.4/100,000/year to 1.4/100,000/year. The reason for GBS though unknown but according to the Centre for Disease Control and Prevention (CDC), about two-thirds of people developed GBS post to gastrointestinal or a respiratory infection. Infectives include Campylobacter jejuni, Zika virus and herpes virus besides pesticides accumulation. Nerves innervating various muscles are affecting showing difficulty in response to the brain signals is one major symptom. Electrodiagnostic study and cerebrospinal liquid (CSF) estimations are the current diagnostics. Intravenous immunoglobulin G and plasmapheresis have been demonstrated to be successful in the treatment.
{"title":"Guillain-Barré Syndrome (GBS)- A Review","authors":"P. Ali, D. Singh, M. Raghavendra, K. Abbulu","doi":"10.38111/ijapb.20190504003","DOIUrl":"https://doi.org/10.38111/ijapb.20190504003","url":null,"abstract":"Guillain-Barré syndrome (GBS), a rare neurological disorder which attack self-immune system especially peripheral nervous system (PNS)and its network of nerves located outside of the brain and spinal cord. GBS has a number of recognized subtypes that have differing clinical and pathophysiological features. Most of the incidence rates of GBS reported was between 1.1/100,000/year and 1.8/100,000/year with lower rates reported in children (less than 16 years) of 0.4/100,000/year to 1.4/100,000/year. The reason for GBS though unknown but according to the Centre for Disease Control and Prevention (CDC), about two-thirds of people developed GBS post to gastrointestinal or a respiratory infection. Infectives include Campylobacter jejuni, Zika virus and herpes virus besides pesticides accumulation. Nerves innervating various muscles are affecting showing difficulty in response to the brain signals is one major symptom. Electrodiagnostic study and cerebrospinal liquid (CSF) estimations are the current diagnostics. Intravenous immunoglobulin G and plasmapheresis have been demonstrated to be successful in the treatment.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80170147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-15DOI: 10.38111/ijapb.20190503002
N. Prashanti, B. Subrahmanyam, G. Rachana, A. Sushma, B. Sharvanabhava
The Chronic Granulomatous Disease is a rare primary immunodeficiency disease, principally attacking white blood cells, characterized by an increased susceptibility to the recurrent bacterial and fungal infections along with the genesis of granulomas in tissue. Staphylococcus and aspergillosis are the main pathogens responsible for majority of infections in CGD. Here we report a case of 5yrs old boy who came with the complaints of fever, cough, and multiple abscess over the right leg, right ankle and left hand with puss discharge. DHR test was performed and have shown the positive results for chronic granulomatous disease. asymptomatic till 3 months of life, then developed pneumonia for which he was ventilated for 5 days. Child has recurrent episodes of LRTI for which IV antibiotics were prescribed. There were no similar complaints in family relating to immune deficiency. Child was immunized as per age profile but has delayed milestones. Immunological studies show normal concentrations of IgA-192 (100-490), IgM-90 (50-320) with mild decrease of IgG-797 (800-1700). Complete blood picture reveals microcytic hypochromic anaemia. Antibiotic sensitivity test was done, and child was found to be sensitive to levofloxacin, imipenem and meropenem.
{"title":"A Case Report on X-Linked Chronic Granulomatous Disease (CGD)","authors":"N. Prashanti, B. Subrahmanyam, G. Rachana, A. Sushma, B. Sharvanabhava","doi":"10.38111/ijapb.20190503002","DOIUrl":"https://doi.org/10.38111/ijapb.20190503002","url":null,"abstract":"The Chronic Granulomatous Disease is a rare primary immunodeficiency disease, principally attacking white blood cells, characterized by an increased susceptibility to the recurrent bacterial and fungal infections along with the genesis of granulomas in tissue. Staphylococcus and aspergillosis are the main pathogens responsible for majority of infections in CGD. Here we report a case of 5yrs old boy who came with the complaints of fever, cough, and multiple abscess over the right leg, right ankle and left hand with puss discharge. DHR test was performed and have shown the positive results for chronic granulomatous disease. asymptomatic till 3 months of life, then developed pneumonia for which he was ventilated for 5 days. Child has recurrent episodes of LRTI for which IV antibiotics were prescribed. There were no similar complaints in family relating to immune deficiency. Child was immunized as per age profile but has delayed milestones. Immunological studies show normal concentrations of IgA-192 (100-490), IgM-90 (50-320) with mild decrease of IgG-797 (800-1700). Complete blood picture reveals microcytic hypochromic anaemia. Antibiotic sensitivity test was done, and child was found to be sensitive to levofloxacin, imipenem and meropenem.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76645134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-15DOI: 10.38111/ijapb.20190503001
J. Chandrashekhar, S. Kalyani, T. S. Vijay, K. Sree, G. Deepa, B. S. Sharavanabhava
{"title":"Prevalence of Stroke in a Tertiary Care Teaching Hospital, Warangal","authors":"J. Chandrashekhar, S. Kalyani, T. S. Vijay, K. Sree, G. Deepa, B. S. Sharavanabhava","doi":"10.38111/ijapb.20190503001","DOIUrl":"https://doi.org/10.38111/ijapb.20190503001","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74287410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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