A Review on Medicinal Plants with Potential Nootropic Activity along with Animal Models Needed for their Screening

T. Chadda, A. C. Rana
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Abstract

Dementia is a brain disorder marked by cognitive dys functioning which causes loss of learning , thinking and memory .Various drugs that possess nootropic activity are used for treatment of dementia but emerges side effects. To overcome these side effects plants with medicinal importance came into existence. India has wide variety of medicinal plants (Centella asiatica, Clitoria ternatea ,Ginkgo biloba, Curcuma longa etc) that has been claimed for nootropic activity with limited side effects. Nootropic activity of medicinal plants can be screened with various animals models that has been able to identify chemicals with potential therapeutic efficacy. The current review article rehabilitates knowledge of medicinal plants with nootropic action, as well as the animal models needed to screen them.
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具有促智活性的药用植物及其筛选所需动物模型的研究进展
痴呆症是一种以认知功能障碍为特征的脑部疾病,它会导致学习、思考和记忆的丧失。各种具有益智活性的药物被用于治疗痴呆症,但会产生副作用。为了克服这些副作用,具有药用价值的植物应运而生。印度有各种各样的药用植物(积雪草、阴蒂、银杏、姜黄等),这些植物被声称具有促智活性,副作用有限。药用植物的促智活性可以通过各种动物模型进行筛选,这些动物模型已经能够识别出具有潜在治疗功效的化学物质。目前的综述文章恢复了具有益智作用的药用植物的知识,以及筛选它们所需的动物模型。
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