2020: murburn concept heralds a new era in cellular bioenergetics

D. A. Gideon, Vivian David Jacob, K. Manoj
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引用次数: 10

Abstract

Cellular bioenergetics has been interpreted for several decades using the Keilin-Mitchell-Boyer (KMB) model of oxidative phosphorylation (OxPhos), and for understanding/managing of the pertinent mitochondrial pathophysiological states. Although decades of research had revealed many faulty chemico-physical aspects of KMB perspective, recent critical insights from our group’s writings have sufficiently brought out the errors in the KMB model, rendering it obsolete/redundant. The murburn model proposed in lieu is a compelling alternative for explaining OxPhos because it reasons several facets of mitochondrial structure-function correlations, reaction chemistry and thermodynamics. However, the mitochondrial research community appears to be recalcitrant, and continues to follow the erstwhile erroneous ideas and not take cognizance of the new insights. Hence, we deemed it opportune to make a clarion call for a jettisoning of the superseded terminologies (or keywords) and concepts routinely used by researchers in this field. First, we present a statistical perspective of the usage of these terms in the past and recent times, to support our claims and call. Then, we articulate simplified arguments why the key elements/terms of the KMB model like “electron-transfer/electron-transport/respiratory chain”, “mitochondrial proton pumps”, “mitochondrial membrane po-tential”, “chemiosmosis”, “proton motive force” and “rotary ATP synthase/synthesis” violate scientific/semantic logic. Finally, we conclude with summative statements projecting the importance of our claims and call.
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2020年:默本概念预示着细胞生物能量学的新时代
细胞生物能量学已经使用氧化磷酸化(OxPhos)的Keilin-Mitchell-Boyer (KMB)模型进行了几十年的解释,并用于理解/管理相关的线粒体病理生理状态。虽然数十年的研究已经揭示了九巴的许多化学和物理方面的错误,但我们小组最近的文章中提出的关键见解已经充分指出了九巴模型中的错误,使其过时/冗余。murburn模型是解释OxPhos的一个令人信服的替代方案,因为它可以解释线粒体结构-功能相关性、反应化学和热力学的几个方面。然而,线粒体研究界似乎很顽固,继续遵循过去的错误观点,而不认识到新的见解。因此,我们认为这是一个机会,使一个响亮的呼吁,抛弃被取代的术语(或关键词)和概念,在这个领域的研究人员经常使用。首先,我们提出了这些术语在过去和最近的使用的统计观点,以支持我们的主张和呼吁。然后,我们阐述了为什么KMB模型的关键要素/术语,如“电子转移/电子传递/呼吸链”、“线粒体质子泵”、“线粒体膜电位”、“化学渗透”、“质子动力”和“旋转ATP合成酶/合成”违反科学/语义逻辑的简化论点。最后,我们以总结性陈述结束,突出我们的要求和呼吁的重要性。
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