Neurophysiology of a double aura in migraine and Alice in wonderland syndrome: Is there a link?

Q3 Medicine Neurology Psychiatry and Brain Research Pub Date : 2019-06-01 DOI:10.1016/j.npbr.2019.02.001

Chirchiglia Domenico, Serena Lavano, Pasquale Chirchiglia

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引用次数: 1

Abstract

Objectives

Alice in Wonderland syndrome (AIWS) is a pathological condition characterized by distortions of visual representation, with symptoms deforming images, figures, bodies, objects, which are seen larger or smaller than normal. Causes are sought in infectious diseases, psychiatric illness, migraines. It may be associated with alterations in the body schema such as non-recognition of own body in space. It's a rare form of visual aura. Unlike it, migraine with aura is a very frequent disorder, in which the phenomenon of visual aura is considered a consequence of cortical spreading depression(CSD), a wave of depolarization that propagates from the occipital cortex, creating a vasoconstriction and visual disturbances.

Methods

Recent studies have found an anatomical correlation between visual and somatosensory disorders such as those found in AIWS, located in the temporo- parieto-occipital junction.Neuroimaging studies allowed to identify the CSD and the occipital cortex responsible for the mechanism of the visual aura and the involvement of the parietal cortex in the genesis of the somatosensory aura.

Results

The mechanism of the initiation of the stage of visual and somatosensory aura could be a combination of two events.

Conclusions

Literature data now offer agreed confirmations on the role of the CSD associated to somatosensory aura.

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偏头痛和爱丽丝梦游仙境综合症双重先兆的神经生理学:有联系吗?

目的爱丽丝梦游仙境综合征(AIWS)是一种以视觉表征扭曲为特征的病理状态，其症状使图像、人物、身体、物体变形，使其看起来比正常情况下更大或更小。病因包括传染病、精神疾病、偏头痛。它可能与身体图式的改变有关，例如在空间中无法识别自己的身体。这是一种罕见的视觉光环。与之不同的是，先兆偏头痛是一种非常常见的疾病，其中视觉先兆现象被认为是皮层扩张性抑制(CSD)的结果，这是一种从枕叶皮层传播的去极化波，造成血管收缩和视觉障碍。方法近年来的研究发现，视觉和躯体感觉障碍(如AIWS)之间存在解剖学上的相关性，这些障碍位于颞顶枕交界处。神经影像学研究可以确定CSD和枕叶皮层负责视觉先兆的机制，以及顶叶皮层参与体感先兆的发生。结果视觉和体感先兆阶段的启动机制可能是两者共同作用的结果。结论:目前的文献资料对CSD与体感先兆相关的作用提供了一致的确认。

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Neurology Psychiatry and Brain Research 医学-精神病学

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.