Are High-Dose Toxic Exposures Always Associated with Reactive Airways Dysfunction Syndrome (RADS)?

Martha A. Hickmann, E. Nelson, Earl G. Siegel, J. Bernstein
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引用次数: 6

Abstract

Abstract Bottling plant workers were evaluated for respiratory symptoms following an accidental exposure to a chlorine dioxide aerosol. Six exposed employees underwent medical and occupational histories, skin testing to common allergens, spirometry before and after use of bronchodilators and methacholine challenge. The reported exposure to chlorine dioxide ranged from 30 min to 12 hr. Physical examinations were all normal. Four workers had positive prick skin tests to common aeroallergens. None of the workers demonstrated significant changes in forced expiratory volume in 1 sec following use of bronchodilators and none experienced methacholine hyperresponsiveness. These cases suggest that the occurrence of reactive airways dysfunction syndrome is unpredictable and may not always occur in heavily exposed individuals.
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高剂量毒性暴露是否总是与反应性气道功能障碍综合征(RADS)有关?
摘要:对装瓶厂工人意外暴露于二氧化氯气溶胶后的呼吸道症状进行了评估。6名暴露的员工接受了病史和职业史、常见过敏原皮肤测试、使用支气管扩张剂前后肺活量测定和甲胆碱挑战。报告的二氧化氯暴露时间为30分钟至12小时。身体检查一切正常。4名工人的皮肤点刺试验对常见的空气过敏原呈阳性反应。使用支气管扩张剂后1秒内用力呼气量无明显变化,无甲胆碱高反应性。这些病例表明,反应性气道功能障碍综合征的发生是不可预测的,可能并不总是发生在重度暴露的个体中。
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