Mood disorder induced by prednisolone – an easily overlooked complication

N. Pang, R. Masiran
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Abstract

Abstract Objective: The use of corticosteroids might be associated with the sequelae of psychiatric comorbidity – manic and depressive symptoms, psychosis, and cognitive impairment. Case report: We report a case of the 35 years old man who presented seven months period of irritability, occasional low mood, and sleep disturbances without the concurrent hallucinations or delusions. The patient had a history of nephrotic syndrome and for this reason, required prednisolone. The corticosteroid induced irritability that has appeared three months after the treatment has started. The psychiatric examination showed neither the psychomotor retardation, manic or depressed mood, nor hallucinations and delusions. However, the level of irritability was undoubtedly increased. Conclusions: Corticosteroids are drugs commonly used in many systemic diseases. During a psychiatric examination, a careful evaluation is necessary to distinguish the side effects of corticosteroids from the primary psychiatric disorders.
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强的松龙引起的情绪障碍——一个容易被忽视的并发症
目的:皮质类固醇的使用可能与精神合并症的后遗症有关——躁狂和抑郁症状、精神病和认知障碍。病例报告:我们报告一例35岁的男性,他表现出7个月的烦躁,偶尔情绪低落,睡眠障碍,没有并发幻觉或妄想。患者有肾病综合征病史,因此需要强的松龙治疗。皮质类固醇引起的易怒在治疗开始三个月后出现。精神病学检查未见精神运动障碍、躁狂或抑郁情绪、幻觉和妄想。然而,烦躁的程度无疑增加了。结论:糖皮质激素是许多全身性疾病的常用药物。在精神检查中,仔细的评估是必要的,以区分皮质类固醇的副作用和原发性精神疾病。
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来源期刊
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审稿时长
15 weeks
期刊介绍: The quarterly Current Problems of Psychiatry is a continuation of the volume "Research on Schizophrenia" and is addressed to a wide group of psychiatrists and clinical psychologists. The quarterly is a reviewed scientific journal of international scope, publishing original papers, review papers, case studies, conference reports, letters to the editor and book reviews. The aim of the "Current Problems of Psychiatry" is providing a wide audience with scientific works, representing a significant contribution to the development of psychiatry and clinical psychology. The works published in the journal are printed in Polish and English. Terms and Conditions for publishing manuscripts in the quarterly are available on the website www.cppsych.umlub.pl in the tab "Requirements".
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