3D printing of costal cartilage models with fine fidelity and biomimetic mechanical performance for ear reconstruction simulation

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL International Journal of Bioprinting Pub Date : 2023-08-03 DOI:10.36922/ijb.1007
Senmao Wang, Di Wang, Liya Jia, Y. Yue, Genli Wu, Yuyun Chu, Qian Wang, Bo Pan, Haiyue Jiang, Lin Lin
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Abstract

 Patient-based training is difficult in ear reconstruction surgery; therefore, costal cartilage models are required for surgical education and pre-operative simulation. Here, we aimed to fabricate personalized models with mechanical and structural similarity to native costal cartilage to simulate ear reconstruction in microtia patients. To achieve this, the stiffness, hardness, and suture retention ability of both native costal cartilage and printed silicone were experimentally examined in vitro. Rheological tests and three-dimensional (3D) comparison methods were used to evaluate the printing ability and outcomes. The printed silicone models were used by residents to practice ear framework handcrafting during ear reconstruction surgery, and the residents’ learning curves were analyzed. In addition, the models were used for pre-operative simulation to study and optimize the surgical plan. The results showed that the consistency of mechanical properties within cartilage and silicone was verified. Printable silicone had good shear-thinning properties, and the printed structures had almost perfect printing fidelity. Residents who used printed silicone models enjoyed great progress and confidence after training. The pre-operative simulation optimized the carving scheme, reduced trauma in the operative site, and avoided wasting necessary cartilage tissue. Overall, fine-fidelity models created in this study were intended for surgical education and pre-operative simulation by applying 3D-printable (3DP) silicone, facilitating the optimization of surgical plans. Surgeons were satisfied with this kind of model and recognized the efficacy and great application value of 3D-printed silicone models for clinical practice.
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3D打印具有良好保真度和仿生力学性能的肋软骨模型用于耳部重建模拟
耳部再造术中以患者为本的训练是困难的;因此,需要肋软骨模型进行手术教育和术前模拟。在这里,我们的目标是制造与天然肋软骨具有机械和结构相似性的个性化模型来模拟小耳症患者的耳部重建。为了实现这一目标,我们在体外实验检测了天然肋软骨和打印硅胶的刚度、硬度和缝线保持能力。采用流变学测试和三维(3D)对比方法来评估打印能力和效果。住院医师在耳廓重建手术中使用打印硅胶模型进行耳架手工制作练习,并分析住院医师的学习曲线。此外,利用模型进行术前模拟,研究和优化手术方案。结果表明,验证了软骨和硅胶内部力学性能的一致性。可打印硅胶具有良好的剪切减薄性能,打印结构具有近乎完美的打印保真度。使用硅胶打印模型的住院医师在培训后进步很大,信心也很足。术前模拟优化了雕刻方案,减少了手术部位的创伤,避免了必要软骨组织的浪费。总的来说,本研究中创建的精细保真模型旨在通过应用3d打印(3D-printable, 3DP)硅胶进行手术教育和术前模拟,促进手术计划的优化。外科医生对这种模型非常满意,也认可了3d打印硅胶模型在临床中的有效性和巨大的应用价值。
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
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