Studies of Physico-chemical Properties and Cytotoxicity of Fruits of Syzygium jambos L. against HeLa and Vero Cell Lines

Fajilatun Nesa, M. Shoeb, Mazharul Islam, N. Islam
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引用次数: 5

Abstract

Syzygium jambos L. belonging to the family Myrtaceae has a long history of using as a dietary fruit and folklore medicine. Investigation of this fruit was carried out to evaluate the different chemical properties and biological activities. The moisture and ash content of the fruit sample were calculated as 86.88 ± 0.61% and 0.29±0.02%, respectively. Dried powder of the fruit was extracted successively with nhexane, dichloromethane (DCM) and methanol (MeOH). UV-Visible and FT-IR spectral analyses confirmed the presence of unsaturated carboxylic acid in n-hexane, unsaturated ester in DCM and a diketone in MeOH extracts. Cytotoxicity assay of different extracts was carried out against HeLa and Vero cell lines and no extract was found to be cytotoxic. Total phenolic contents of the n-hexane, DCM and MeOH extracts were 15.39 ± 0.24, 31.32 ± 0.25 and 42.19 ± 0.16 mg gallic acid equivalent per gram of dry extract, respectively and total flavonoid content of n-hexane, DCM and MeOH extracts were 6.52 ± 0.18, 15.55 ± 0.16 and 8.36 ± 0.16 mg quercetin equivalent per gram of dry extract, respectively. This study establishes that S. jambos fruit can be a potential source of natural antioxidants. Bangladesh Pharmaceutical Journal 24(2): 111-116, 2021
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杨木果实对HeLa和Vero细胞株的理化性质及细胞毒性研究
枸杞属桃科,作为食用水果和民间医药有着悠久的历史。对该果实进行了研究,以评价其不同的化学性质和生物活性。果实样品的水分和灰分含量分别为86.88±0.61%和0.29±0.02%。用己烷、二氯甲烷(DCM)和甲醇(MeOH)依次提取果粉。紫外可见光谱和红外光谱分析证实,正己烷中存在不饱和羧酸,DCM中存在不饱和酯,甲醇提取物中存在二酮。不同提取物对HeLa和Vero细胞株进行了细胞毒性试验,均未发现提取物具有细胞毒性。正己烷、DCM和MeOH提取物的总酚含量分别为15.39±0.24、31.32±0.25和42.19±0.16 mg没食子酸当量/ g干提取物;总黄酮含量分别为6.52±0.18、15.55±0.16和8.36±0.16 mg槲皮素当量/ g干提取物。这项研究表明,大叶果可能是天然抗氧化剂的潜在来源。孟加拉国药学杂志24(2):111-116,2021
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