Efficient Synthesis, In-Vitro Antioxidant, Anticancer and Molecular Docking Studies of Bidentate Schiff Base Complexes of Vo(Ii) and Zn(Ii) by Green Route Method

Abstract

Vanadium(II) and Zn(II) chelates with Schiff base derived from the condensation of orthophenylenediamine and cinnamaldehyde. Schiff base are multilateral ligand and offer resistant series of ligand to coordinate with metals. The Schiff base and its metal complexes were synthesized and characterized by elemental analysis, metal estimation, molar conductance, magnetic moment, UV-Visible, IR, Far-IR and NMR spectral studies. The elemental analysis suggest the stoichiometry to be 1:1 (M:L).The complexes are non-electrolyte in acetonitrile solution. The molar conductance and spectral properties indicate the complexes don’t dissociate in acetonitrile solution and retain their coordination. Melting points support the thermal stability of the complex. Coordination of ligand was confirmed by constant change of FT-IR. The electronic spectral data support octahedral geometry of VO(II) and square planar geometry of Zn(II) complexes. IR spectral data suggest that the ligand coordinated to the metal ion by imino nitrogen and amine nitrogen as bidentate manner. The NMR (1H & 13C) spectrum of schiff base and its diamagnetic Zn(II) complex was carried out and confirmed by the geometry and magnetic property of them. The antibacterial activity of the schiff base and VO(II) and Zn(II) complexes was assessed against Staphylococcus aureus, Enterococcus as Gram-positive bacteria and further against Escherichia coli, Vibrio parahaemolyticus and Pseudomonas as Gram–negative bacteria and one pathogenic yeast C.albicans by agar well diffusion method. The results of anticancer activity of schiff base and VO(II) and Zn(II) complexes indicated that the metal complex have moderately active than the corresponding ligand. The cell cycle proteins, CDK4 (PDB ID: 3G33), P-53 (PDB ID: 1YCS) were downloaded from the RCSB PDB (protein data bank) database and the auto Dock (V. 4.0) in the PyRx GUI has been used to confirm the binding abilities of the selected ligand and VO(II) complex.