Fabio Angelo Di Giuseppe, F. Coffigniez, C. Aouf, V. Guillard, E. Torrieri
A coupled experimental and modelling approach was developped to characterize the radical inhibition and oxygen scavenger properties of gallic acid/ sodium carbonate mixture included in a PHBV film. PHBV active packaging was produced by thermoforming. In contact with acqueous and fatty food simulants, almost 30% of the initial gallic acid was released into food simulants A (10% ethanol), and D1 (50% ehtanol), where it showed a radical inhibition value (I%) reaching 68±0.1% and 77±0.1% respectively, while no release was observed in food simulant D2 (isooctane). In addition, the active films displayed an O2 scanvenger capacity of 120 mg O2g-1 GA at room temperature, after 10 days of storage. Models showed a good fitting to experimental data. The PHBV active packaging combining both antiradical and oxygen scavenger activities, is very promising for food protection. However, some improvements are still needed to enhance its oxygen barrier capacity and to meet the reglementation.
{"title":"Activated Gallic Acid as Radical and Oxygen Scavenger in Biodegradable Packaging Film","authors":"Fabio Angelo Di Giuseppe, F. Coffigniez, C. Aouf, V. Guillard, E. Torrieri","doi":"10.2139/ssrn.3897775","DOIUrl":"https://doi.org/10.2139/ssrn.3897775","url":null,"abstract":"A coupled experimental and modelling approach was developped to characterize the radical inhibition and oxygen scavenger properties of gallic acid/ sodium carbonate mixture included in a PHBV film. PHBV active packaging was produced by thermoforming. In contact with acqueous and fatty food simulants, almost 30% of the initial gallic acid was released into food simulants A (10% ethanol), and D1 (50% ehtanol), where it showed a radical inhibition value (I%) reaching 68±0.1% and 77±0.1% respectively, while no release was observed in food simulant D2 (isooctane). In addition, the active films displayed an O2 scanvenger capacity of 120 mg O2g-1 GA at room temperature, after 10 days of storage. Models showed a good fitting to experimental data. The PHBV active packaging combining both antiradical and oxygen scavenger activities, is very promising for food protection. However, some improvements are still needed to enhance its oxygen barrier capacity and to meet the reglementation.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79515721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Present investigation demonstrates application of pine leaves as green friendly source for production of biochar (BC) that could to transformed into graphene oxide (GO) for sustained electrochemical energy storage (EES) and corrosion protection in KOH (2.0 M). For this purpose, BC was prepared through pyrolysis of pine leaves (moisture content 78.09 %) at 750 o C over 3 h in nitrogen environment. GO was synthesized through modification in Hammer’s method. Formation of BC and GO was ascertained through Fourier transform infrared, Raman and X-ray diffraction spectra. Working electrodes (WE) were fabricated from BC (WE BC ) and GO (WE GO ) in presence of hydroxy methyl propyl cellulose as binder and their morphologies were compared through scanning electron microscopy. WE were electrochemically analyzed through cyclic voltammetry (CV), electrochemical impedance spectra (EIS) and potentiodynamic polarization in KOH (2.0 M). CV @ 0.005 V/s in potential window of -0.71 V to -0.21 V reveals 390.4 F/g of Cs of WE GO that was 24.49 % improved over WE BC . EIS in frequency response (KHz) ranging 1.0 × 10 -5 Hz to 100 at ± 0.005 V reveals stability of WE over 24 h. Potentiodynamic polarization in the potential ranging -1.5 to 1.0 @ 0.005 V/s reveals corrosion rate (mm/year) of WE GO @ 4.69 × 10 -4 that was much reduced over WE BC (2.27 × 10 -3 ) under identical conditions.
{"title":"Sustainable Development of Graphene Oxide from Pine Leaves for Electrochemical Energy Storage and Corrosion Protection","authors":"K. Singhal, S. Mehtab, M. Pandey, M. Zaidi","doi":"10.2139/ssrn.3926131","DOIUrl":"https://doi.org/10.2139/ssrn.3926131","url":null,"abstract":"Present investigation demonstrates application of pine leaves as green friendly source for production of biochar (BC) that could to transformed into graphene oxide (GO) for sustained electrochemical energy storage (EES) and corrosion protection in KOH (2.0 M). For this purpose, BC was prepared through pyrolysis of pine leaves (moisture content 78.09 %) at 750 o C over 3 h in nitrogen environment. GO was synthesized through modification in Hammer’s method. Formation of BC and GO was ascertained through Fourier transform infrared, Raman and X-ray diffraction spectra. Working electrodes (WE) were fabricated from BC (WE BC ) and GO (WE GO ) in presence of hydroxy methyl propyl cellulose as binder and their morphologies were compared through scanning electron microscopy. WE were electrochemically analyzed through cyclic voltammetry (CV), electrochemical impedance spectra (EIS) and potentiodynamic polarization in KOH (2.0 M). CV @ 0.005 V/s in potential window of -0.71 V to -0.21 V reveals 390.4 F/g of Cs of WE GO that was 24.49 % improved over WE BC . EIS in frequency response (KHz) ranging 1.0 × 10 -5 Hz to 100 at ± 0.005 V reveals stability of WE over 24 h. Potentiodynamic polarization in the potential ranging -1.5 to 1.0 @ 0.005 V/s reveals corrosion rate (mm/year) of WE GO @ 4.69 × 10 -4 that was much reduced over WE BC (2.27 × 10 -3 ) under identical conditions.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84595233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ojeyemi M. Olabemiwo, S. Akintelu, Aisha A. Waheed, Dasola S. Okunlola, Darasimi R. Akinwale, Gbadebo C. Adeyinka, Tomiwa W. Adeniji, Segun A. Adebisi
The green synthesis of nanoparticles has been a vital aspect in the search for novel antimicrobial agents. This research aimed at biosynthesis, characterization and preliminary evaluation of the antibacterial properties of silver nanoparticles (AgNPs) from the back extract of Annona senegalensisis. The bark of Annona senegalensis was scraped from the stem, washed, air-dried, pulverised and extracted. Fourier transform infrared (FTIR) analysis was carried out on the synthesized AgNPs. The AgNPs synthesized was also characterized with UV-visible spectrophotometer (UV), scanning electron microscope, transmission electron microscopy, energy-dispersive X-ray spectroscopy to ascertain the physico-chemical and morphological properties of the AgNPs. The antimicrobial investigation was carried out following standard method. The observation of colour change (pale yellow to dark brown) during the synthesis and maximum absorbance at wavelength 431.19nm in the UV spectrum confirmed the formation of AgNPs. The FTIR analysis showed that the biomolecules responsible for the reduction of silver ion contain O-H functional groups. The electron microscopy studies indicated that the AgNPS are spherical in shape with nanoparticles sizes of 11- 24.76nm. EDX analysis showed that the AgNPs contain high amount of silver and few other elements. The antimicrobial study showed high zones of inhibition 22.75-33.75 against tested bacteria. The simplicity of the synthesis of AgNPs from the extract of the stem bark of Annona senegalensis is and relatively high zones of inhibitions shown by the AgNPs are strong evidences of the possible application of Annona senegalensis is in the synthesis of novel therapeutic agent against infections from bacteria and fungi.
{"title":"Green Synthesis of Silver Nanoparticles Using Stem Bark Extract of Annona senegalensis: Characterization and Its Antibacterial Potency","authors":"Ojeyemi M. Olabemiwo, S. Akintelu, Aisha A. Waheed, Dasola S. Okunlola, Darasimi R. Akinwale, Gbadebo C. Adeyinka, Tomiwa W. Adeniji, Segun A. Adebisi","doi":"10.2139/ssrn.3935549","DOIUrl":"https://doi.org/10.2139/ssrn.3935549","url":null,"abstract":"The green synthesis of nanoparticles has been a vital aspect in the search for novel antimicrobial agents. This research aimed at biosynthesis, characterization and preliminary evaluation of the antibacterial properties of silver nanoparticles (AgNPs) from the back extract of Annona senegalensisis. The bark of Annona senegalensis was scraped from the stem, washed, air-dried, pulverised and extracted. Fourier transform infrared (FTIR) analysis was carried out on the synthesized AgNPs. The AgNPs synthesized was also characterized with UV-visible spectrophotometer (UV), scanning electron microscope, transmission electron microscopy, energy-dispersive X-ray spectroscopy to ascertain the physico-chemical and morphological properties of the AgNPs. The antimicrobial investigation was carried out following standard method. The observation of colour change (pale yellow to dark brown) during the synthesis and maximum absorbance at wavelength 431.19nm in the UV spectrum confirmed the formation of AgNPs. The FTIR analysis showed that the biomolecules responsible for the reduction of silver ion contain O-H functional groups. The electron microscopy studies indicated that the AgNPS are spherical in shape with nanoparticles sizes of 11- 24.76nm. EDX analysis showed that the AgNPs contain high amount of silver and few other elements. The antimicrobial study showed high zones of inhibition 22.75-33.75 against tested bacteria. The simplicity of the synthesis of AgNPs from the extract of the stem bark of Annona senegalensis is and relatively high zones of inhibitions shown by the AgNPs are strong evidences of the possible application of Annona senegalensis is in the synthesis of novel therapeutic agent against infections from bacteria and fungi.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85040482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-19DOI: 10.1016/J.POLY.2021.115161
S. Kaushal, Parul Kurichh, K. Kaur, P. Singh
{"title":"Novel 3D Flower Like ZnO/MnV 2O 6 Heterojunction as an Efficient Adsorbent for the Removal of Imidacloprid and Photocatalyst for Degradation of Organic Dyes in Waste Water","authors":"S. Kaushal, Parul Kurichh, K. Kaur, P. Singh","doi":"10.1016/J.POLY.2021.115161","DOIUrl":"https://doi.org/10.1016/J.POLY.2021.115161","url":null,"abstract":"","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76903462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-03DOI: 10.21203/RS.3.RS-258541/V1
Xiu-Yuan Li, Ying-Bo Wang, Song Yan, Xiang Dan, Chaozheng He
A new porous metal-organic framework, [Pb5(Ac)7(nIm)3]n (1), has been successfully synthesized by employing 2-nitroimidazole ligand and Pb2+ ion. 1 contains novel the ribbon-shaped Pb-O SBU and reveals a 2D porous framework with a 1D tubular channel. Moreover, 1 shows moderate adsorption uptake towards CO2 and luminescence properties from intraligand charge transfer. We further confirmed nitro group and metal ion are important adsorption sites by GCMC simulations, and the electronic structures of 1 was investigated.
{"title":"A 2D Porous Pb-MOF Based on 2-Nitroimidazole: CO 2 Adsorption, Electronic Structure and Luminescence","authors":"Xiu-Yuan Li, Ying-Bo Wang, Song Yan, Xiang Dan, Chaozheng He","doi":"10.21203/RS.3.RS-258541/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-258541/V1","url":null,"abstract":"\u0000 A new porous metal-organic framework, [Pb5(Ac)7(nIm)3]n (1), has been successfully synthesized by employing 2-nitroimidazole ligand and Pb2+ ion. 1 contains novel the ribbon-shaped Pb-O SBU and reveals a 2D porous framework with a 1D tubular channel. Moreover, 1 shows moderate adsorption uptake towards CO2 and luminescence properties from intraligand charge transfer. We further confirmed nitro group and metal ion are important adsorption sites by GCMC simulations, and the electronic structures of 1 was investigated.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83502997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reduced Graphene oxide (rGO) behaves as an excellent heterogeneous catalyst because of its remarkable characteristics such as large specific surface area and high thermal stability. In this regards, Graphene oxide was converted to magnetic nanohybrid (CoFe@rGO) and utilized as an efficient heterogeneous catalyst for the ring opening reactions and act as Lewis acid to promote the reaction. Developed a new facile, environmentally benign and green methodology for the synthesis of β-hydroxytriazoles and β- N -tosylsulfonamidetriazoles derivatives via ring opening reaction of epoxides and aziridines respectively in the presence of CoFe@rGO nanohybrid as catalyst in good to excellent yields under solvent free reaction conditions. Catalyst was separated from the reaction mixture by an external magnet, recycled and reused up to six catalytic runs without significant loss of catalytic activity. Environmentally benign conditions, cheap starting materials, shorter reaction times, easy work-up and purification of the products, high regioselectivity, high yields, recyclability and reusability of catalyst are the main advantages of our protocol.
还原氧化石墨烯(rGO)具有比表面积大、热稳定性高等特点，是一种优良的非均相催化剂。为此，将氧化石墨烯转化为磁性纳米杂化物(CoFe@rGO)，作为开环反应的高效非均相催化剂，并作为Lewis酸促进反应。在无溶剂条件下，以CoFe@rGO纳米杂化物为催化剂，通过环氧化合物开环反应合成β-羟基三唑衍生物和β- N -甲基磺酰胺三唑衍生物，获得了一种简便、环保、绿色的新方法。催化剂通过外部磁铁从反应混合物中分离出来，回收和重复使用多达六次催化运行，而没有明显的催化活性损失。环境友好的条件，廉价的起始材料，较短的反应时间，易于加工和纯化的产品，高区域选择性，高收率，催化剂的可回收性和可重复使用是我们的方案的主要优点。
{"title":"Ring Opening of Epoxides and Aziridines with Benzotriazoles Using Magnetically Retrievable Graphene Based (CoFe@rGO) Nanohybrid","authors":"A. Sheoran, J. Kaur, J. Agarwal, S. Singhal","doi":"10.2139/SSRN.3775834","DOIUrl":"https://doi.org/10.2139/SSRN.3775834","url":null,"abstract":"Reduced Graphene oxide (rGO) behaves as an excellent heterogeneous catalyst because of its remarkable characteristics such as large specific surface area and high thermal stability. In this regards, Graphene oxide was converted to magnetic nanohybrid (CoFe@rGO) and utilized as an efficient heterogeneous catalyst for the ring opening reactions and act as Lewis acid to promote the reaction. Developed a new facile, environmentally benign and green methodology for the synthesis of β-hydroxytriazoles and β- N -tosylsulfonamidetriazoles derivatives via ring opening reaction of epoxides and aziridines respectively in the presence of CoFe@rGO nanohybrid as catalyst in good to excellent yields under solvent free reaction conditions. Catalyst was separated from the reaction mixture by an external magnet, recycled and reused up to six catalytic runs without significant loss of catalytic activity. Environmentally benign conditions, cheap starting materials, shorter reaction times, easy work-up and purification of the products, high regioselectivity, high yields, recyclability and reusability of catalyst are the main advantages of our protocol.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"2885 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86514527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-11DOI: 10.1016/J.POLY.2021.115226
Sujaya Chakraborty, Ayan K. Patra, Asit Mondal, Somenath Lohar, E. Zangrando, P. Chattopadhyay
{"title":"A New Phenolato-Bridged Dinuclear Manganese(II) Complex as a Turn-On Fluorosensor for Zn 2+ Ions Via Mn 2+ Ion Replacement","authors":"Sujaya Chakraborty, Ayan K. Patra, Asit Mondal, Somenath Lohar, E. Zangrando, P. Chattopadhyay","doi":"10.1016/J.POLY.2021.115226","DOIUrl":"https://doi.org/10.1016/J.POLY.2021.115226","url":null,"abstract":"","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81350170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mehboob, Riaz Hussain, Zobia Irshad, Muhammad Adnan
An efficient molecular modelling approaches drawing a great attention from the scientific community to further boost the photovoltaic performances of the solar cell’s materials. For this purpose, various end-capped and bridged-core modifications have been carried-out to construct a suitable molecule best fitted for solar cell applications. Herein, we have designed a small-molecule based fullerene-free acceptor materials (IOD1-IOD7) for organic solar cells (OSCs) by doing end-capped modifications, and characterized them theoretically by employing various quantum chemical density functional theory (DFT) and time-dependent (DFT) approaches. The specific key features of the designed materials (IOD1-IOD7) essential for the solar cell applications have been estimated by investigating their absorption maxima, reorganization energy and open-circuit voltages (Voc) values. The other key parameters such as, electronic structures, frontier molecular orbitals, exciton binding energy, and charge transfer phenomenon has also been studied theoretically. The outcomes of these theoretical characterizations revealed that all the newly designed non-fullerene acceptor materials exhibit a wide-ranging absorption efficiency and exciton dissociation constant values, with quite lower LUMO energy level, ensuring a boost in various photo-physical and in opto-electronic properties of the designed materials, which will eventually improve the power conversion efficiency (PCE) of the OSCs devices.
{"title":"First Principle Theoretical Designing of U-Shaped Fullerene-Free Acceptor Molecules for Efficient Indoor and Outdoor Organic Solar Cell Applications","authors":"M. Mehboob, Riaz Hussain, Zobia Irshad, Muhammad Adnan","doi":"10.2139/ssrn.3783159","DOIUrl":"https://doi.org/10.2139/ssrn.3783159","url":null,"abstract":"An efficient molecular modelling approaches drawing a great attention from the scientific community to further boost the photovoltaic performances of the solar cell’s materials. For this purpose, various end-capped and bridged-core modifications have been carried-out to construct a suitable molecule best fitted for solar cell applications. Herein, we have designed a small-molecule based fullerene-free acceptor materials (IOD1-IOD7) for organic solar cells (OSCs) by doing end-capped modifications, and characterized them theoretically by employing various quantum chemical density functional theory (DFT) and time-dependent (DFT) approaches. The specific key features of the designed materials (IOD1-IOD7) essential for the solar cell applications have been estimated by investigating their absorption maxima, reorganization energy and open-circuit voltages (Voc) values. The other key parameters such as, electronic structures, frontier molecular orbitals, exciton binding energy, and charge transfer phenomenon has also been studied theoretically. The outcomes of these theoretical characterizations revealed that all the newly designed non-fullerene acceptor materials exhibit a wide-ranging absorption efficiency and exciton dissociation constant values, with quite lower LUMO energy level, ensuring a boost in various photo-physical and in opto-electronic properties of the designed materials, which will eventually improve the power conversion efficiency (PCE) of the OSCs devices.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85738714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ersin Orhan, Görkem Dülger, M. Alpay, Nilüfer Öksüz, B. Dülger
Some novel the benzimidazole-bridged aren ruthenium rectangles compounds of the general structure [{Ru2(p-cymene)2(µ4-OOᴖOO)}2(µ4-bbim)]4+ (bbim = 1,1'-butyl-2-ene-di(benzimidazole) were obtained from the corresponding double nuclear arene ruthenium compounds [Ru2(p-cymene)2(µ4-OOᴖOO)Cl2] (OOᴖOO = 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dibromo-1,4-benzoquinonato (dBrbq), oxalato (oxa), 5,8-dioxido-1,4-naphtoquinonato (donq) by reaction with the bbim molecule and AgCF3SO3. The antiproliferative activity of the tetranuclear arene ruthenium compounds was evaluated on their anti-cancer properties against human breast cancer cell line (MDA-231-MB), compound 2 showed the highest antiproliferative effect among the other compounds during 24 and 48 hours administration. Also, other all compounds showed very good cancer cell selectivity and very low micromolar cytotoxicities. In addition, antimicrobial activities of the synthesized compounds were determined. Against ten bacteria (such as Escherichia coli ATCC10536, Staphylococcus aureus ATCC 6538P, Staphylococcus epidermidis ATCC 12228, Klebsiella pneumoniae UC57, Proteus vulgaris ATCC 8427, Pseudomonas aureginosa ATCC 27853, Enterococcus faecalis ATCC 29212, Citrobacter freundii ATCC 8090, Mycobacterium smagmatis CCM 2067 and Listeria monocytogenes ATCC 15313) and seven yeast cultures (such as Candida glabrata ATCC 90030, Candida tropicalis ATCC 13803, Candida albicans ATCC 10231, Kluyveromyces fragilis NRRL 2415, Rhodotorula rubra DSM 70403, Debaryomyces hanseni DSM 70238, Hanseniaspora guillermondii DSM 3432). Using the disk diffusion method as well as the minimal inhibitory concentration (MIC) dilution method. Especially, the compounds exhibit potential antibacterial effects against Gram negative bacteria than Gram positive bacteria and showed superior antifungal effect agaist candida species. The results revealed that the benzimidazole-bridged aren ruthenium rectangles compounds were the very strong potent inhibitor.
{"title":"Antimicrobial and Antiproliferative Activities of New Benzimidazole-Bridged Aren Ruthenium Rectangles in Human Breast Cancer Cells","authors":"Ersin Orhan, Görkem Dülger, M. Alpay, Nilüfer Öksüz, B. Dülger","doi":"10.2139/ssrn.3770116","DOIUrl":"https://doi.org/10.2139/ssrn.3770116","url":null,"abstract":"Some novel the benzimidazole-bridged aren ruthenium rectangles compounds of the general structure [{Ru2(p-cymene)2(µ4-OOᴖOO)}2(µ4-bbim)]4+ (bbim = 1,1'-butyl-2-ene-di(benzimidazole) were obtained from the corresponding double nuclear arene ruthenium compounds [Ru2(p-cymene)2(µ4-OOᴖOO)Cl2] (OOᴖOO = 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dibromo-1,4-benzoquinonato (dBrbq), oxalato (oxa), 5,8-dioxido-1,4-naphtoquinonato (donq) by reaction with the bbim molecule and AgCF3SO3. The antiproliferative activity of the tetranuclear arene ruthenium compounds was evaluated on their anti-cancer properties against human breast cancer cell line (MDA-231-MB), compound 2 showed the highest antiproliferative effect among the other compounds during 24 and 48 hours administration. Also, other all compounds showed very good cancer cell selectivity and very low micromolar cytotoxicities. In addition, antimicrobial activities of the synthesized compounds were determined. Against ten bacteria (such as Escherichia coli ATCC10536, Staphylococcus aureus ATCC 6538P, Staphylococcus epidermidis ATCC 12228, Klebsiella pneumoniae UC57, Proteus vulgaris ATCC 8427, Pseudomonas aureginosa ATCC 27853, Enterococcus faecalis ATCC 29212, Citrobacter freundii ATCC 8090, Mycobacterium smagmatis CCM 2067 and Listeria monocytogenes ATCC 15313) and seven yeast cultures (such as Candida glabrata ATCC 90030, Candida tropicalis ATCC 13803, Candida albicans ATCC 10231, Kluyveromyces fragilis NRRL 2415, Rhodotorula rubra DSM 70403, Debaryomyces hanseni DSM 70238, Hanseniaspora guillermondii DSM 3432). Using the disk diffusion method as well as the minimal inhibitory concentration (MIC) dilution method. Especially, the compounds exhibit potential antibacterial effects against Gram negative bacteria than Gram positive bacteria and showed superior antifungal effect agaist candida species. The results revealed that the benzimidazole-bridged aren ruthenium rectangles compounds were the very strong potent inhibitor.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86461038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herein, we report the gold(I)-MIC complexes (1-3), bearing mesoionic carbene (MIC) ligands were synthesized. The catalytic activities of these gold(I)-MIC complexes were found to be highly effective catalysts for cyanosilylation of various aldehydes under solvent-free conditions using TMSCN (trimethylsilyl cyanide). The cyano group transfer from TMSCN to aldehydes proceeds at room temperature in the presence of only 5 mol % of Au(I)-MIC catalysts (1-3), to produce value-added cyanohydrin trimethylsilyl ethers in very good to excellent yields within 6 h, from various aldehydes through cyanosilylation process by using trimethylsilyl cyanide reagent at room temperature under solvent-free condition. These reaction conditions are extremely mild and simple and tolerate various functional groups.
{"title":"Gold(I)-MIC Complexes as a Highly Effective Catalyst for the Cyanosilylation of Carbonyl Compounds Under Solvent-Free Condition","authors":"M. Gangwar","doi":"10.2139/ssrn.3761020","DOIUrl":"https://doi.org/10.2139/ssrn.3761020","url":null,"abstract":"Herein, we report the gold(I)-MIC complexes (<b>1-3</b>), bearing mesoionic carbene (MIC) ligands were synthesized. The catalytic activities of these gold(I)-MIC complexes were found to be highly effective catalysts for cyanosilylation of various aldehydes under solvent-free conditions using TMSCN (trimethylsilyl cyanide). The cyano group transfer from TMSCN to aldehydes proceeds at room temperature in the presence of only 5 mol % of Au(I)-MIC catalysts (<b>1-3</b>), to produce value-added cyanohydrin trimethylsilyl ethers in very good to excellent yields within 6 h, from various aldehydes through cyanosilylation process by using trimethylsilyl cyanide reagent at room temperature under solvent-free condition. These reaction conditions are extremely mild and simple and tolerate various functional groups.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"15 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83148679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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