Genetic factors in uterine fibromatosis

Abstract

Uterine fibroids represent the most commonly encountered benign tumors among women at childbearing age which might significantly influence their capacity of carring a normal pregnancy. Therefore, due to the significant impact which might be encountered, attention was focused on determining which are the most important risk factors for developing such lesions. In this respect, nowadays particular attention was given to genetic factors. In this article we discuss the implications of genetic chromosomal abnormalities as well as chromosomal rearrangements in the formation of fibroids. We also report diseases that should not be overlooked when differentially diagnosing leiomyomatosis (MCUL1 and HLRCC).