Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping.

Physiological zoology Pub Date : 2019-08-12 DOI:10.3791/59592

Bradford Z Mahon, Jeffrey A Mead, Benjamin L Chernoff, Maxwell H Sims, Frank E Garcea, Emily Prentiss, Raouf Belkhir, Sam J Haber, Sarah B Gannon, Steve Erickson, Kelly A Wright, Michael Z Schmidt, Audrey Paulzak, Vanessa C Milano, David A Paul, Kenneth Foxx, Madalina Tivarus, Jacob W Nadler, Jacqueline M Behr, Susan O Smith, Yan Michael Li, Kevin Walter, Webster H Pilcher

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Abstract

The Translational Brain Mapping Program at the University of Rochester is an interdisciplinary effort that integrates cognitive science, neurophysiology, neuroanesthesia, and neurosurgery. Patients who have tumors or epileptogenic tissue in eloquent brain areas are studied preoperatively with functional and structural MRI, and intraoperatively with direct electrical stimulation mapping. Post-operative neural and cognitive outcome measures fuel basic science studies about the factors that mediate good versus poor outcome after surgery, and how brain mapping can be further optimized to ensure the best outcome for future patients. In this article, we describe the interdisciplinary workflow that allows our team to meet the synergistic goals of optimizing patient outcome and advancing scientific understanding of the human brain.

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罗切斯特大学医学中心的转化脑图谱：通过个性化脑图谱保护心灵。

罗切斯特大学的转化脑图谱计划是一项整合了认知科学、神经生理学、神经麻醉学和神经外科的跨学科工作。术前通过功能性和结构性核磁共振成像，术中通过直接电刺激映射，对在脑功能区有肿瘤或致痫组织的患者进行研究。术后神经和认知结果测量促进了基础科学研究，这些研究涉及术后良好与不良结果的介导因素，以及如何进一步优化脑图谱以确保未来患者获得最佳结果。在这篇文章中，我们介绍了跨学科工作流程，该流程使我们的团队能够实现优化患者预后和促进对人脑的科学理解这两个协同目标。

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Physiological zoology

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