QT Interval Prolongation and Atypical Proarrhythmia: Monomorphic Ventricular Tachycardia with Trimebutine

M. Schiariti, A. Saladini, A. Placanica, Marta Saolini, P. Puddu
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引用次数: 3

Abstract

A 59-year old woman was admitted at emergency for palpitation and dizziness. Medication history showed trimebutine 450 mg daily, because of meteorism, increased to 450 mg TID a week earlier. At admittance, sustained monomorphic ventricular tachycardia was interrupted by 100 mg intravenous lidocaine and a largely prolonged QTc (523 ± 12 ms) was seen. Discontinuation of trimebutine achieved normalisation of QTc (420 ± 10 ms, p<0.001). This is the first report in man to illustrate a probable proarrhythmic action of trimebutine. A weak inhibitory effect on both rapid and slow components of the delayed rectifier in guinea-pig ventricular myocytes calls for further investigations in human myocardial tissues. Trimebutine inhibition of Na + and Ca ++ channels in cardiac tissues of rabbits and guinea-pigs also call for further studies in human myocardial tissues.
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QT间期延长和非典型心律失常:曲美布汀治疗单纯性室性心动过速
一名59岁妇女因心悸和头晕而入院急诊。用药史显示曲美布汀每日450毫克,由于气象,一周前增加到每日450毫克。入院时,静脉注射100 mg利多卡因可中断持续性单型室性心动过速,QTc明显延长(523±12 ms)。停用曲美布汀后QTc恢复正常(420±10 ms, p<0.001)。这是人类首次报道曲美布汀可能的心律失常作用。对豚鼠心室肌细胞延迟整流的快速和慢速组分的微弱抑制作用需要在人类心肌组织中进一步研究。曲美布汀对家兔和豚鼠心脏组织中Na +和Ca ++通道的抑制作用也需要在人类心肌组织中进一步研究。
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