Hepatoprotective Activity of Tectona grandis Against CCl4-Induced Hepatic Damage in Rats

Geeta Deswal, Kumar Guarve, P. Kriplani, A. Dhingra, B. Chopra, J. Sidana
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引用次数: 1

Abstract

The preliminary phytochemical studies confirmed the existence of saponins, carbohydrates, tannins, and flavonoids. CCl4 treated group boost the concentrations of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphate (ALP) and serum bilirubin as compared to control group (rats treated with vehicle). The methanolic extract of plant (200 mg/kg & 400 mg/kg) and standard drug silymarin (100 mg/kg) produced a significant decrease in raised levels of these enzymes as compared to control.
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大构造对ccl4致大鼠肝损伤的保护作用
初步的植物化学研究证实了皂苷、碳水化合物、单宁和类黄酮的存在。CCl4处理组血清谷氨酸丙酮酸转氨酶(SGPT)、谷氨酸草酰乙酸转氨酶(SGOT)、碱性磷酸酶(ALP)和血清胆红素浓度均高于对照组(载药组)。与对照组相比,植物甲醇提取物(200 mg/kg和400 mg/kg)和标准药物水飞蓟素(100 mg/kg)显著降低了这些酶的升高水平。
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