A Case of Altered Mental Status in the Setting of Bromethalin Toxicity

M. Bayoumi, K. Muddassir
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Abstract

Bromethalin is one of four different types of rodenticide ingredients. Accidental or intentional ingestion of that poison can cause serious symptoms and signs that would require hospitalization and might lead to death. It works by depleting ATP from brain and liver mitochondria by uncoupling of oxidative phosphorylation process which leads to disruption of the function of sodium/potassium ion pumps in those organs causing cerebral edema with intracranial hypertension. Our case presented with altered mental status after patient was found down in his car with green discoloration around mouth and holding Tomcat rat poison in one hand and a bottle of Vodka on the other hand. Patient was intubated and admitted to ICU. Supportive care was started and later on was weaned off mechanical ventilation and improved over the course of his hospital stay.
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溴甲烷中毒后精神状态改变1例
溴甲基灵是四种不同类型的灭鼠剂成分之一。意外或故意摄入这种毒药会导致严重的症状和体征,需要住院治疗,并可能导致死亡。它的作用原理是通过氧化磷酸化过程的解偶联,消耗脑和肝脏线粒体的ATP,导致这些器官钠/钾离子泵功能的破坏,引起脑水肿伴颅内压增高。在我们的案例中,病人被发现倒在他的车里,嘴巴周围变色,一只手拿着雄猫老鼠药,另一只手拿着一瓶伏特加,精神状态发生了改变。患者插管后住进ICU。开始了支持性护理,后来停止了机械通气,并在住院期间有所改善。
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