Design, Fabrication, and Analysis of Resveratrol and Piperine-Loaded Chitosan Nanoparticles with the Purpose of Providing an Enhanced Parkinson's Disease Treatment

Abstract

Nanoformulation plays an essential function in emphasising the efficiency of reaching medications such as chemotherapeutic treatments and phytochemicals, and this significance is becoming increasingly recognised. In the course of this experiment, we focused on increasing the bioavailability of resveratrol lby loading it into nanoparticles. Doing so has the potential to reduce the toxicity that is a side effect of conventional formulation as well as minimise the amount of times a dose needs to be administered. The polymer, in its capacity as a carrier, plays a vital role in transporting the drug over the blood-brain barrier, which may be effective in bringing about the desired therapeutic effect. Piperine, acting as both a bio enhancer and an MAO inhibitor, has the potential to not only boost the effectiveness of resveratrol but also provide an additional mode of action that can be used to treat Parkinson's disease in a manner that is both efficient and effective. Additionally, piperine has the potential to be used in place of MAO-B inhibitors like selegline and rosagline. This provides a boost to the ongoing work on particle size in relation to two different medications and a polymer.