{"title":"Synthesis and preliminary evaluation of a molecularly imprinted polymer selective for artificial phenolic estrogenic compounds","authors":"J. Tarbin, M. Sharman","doi":"10.1039/A900197B","DOIUrl":null,"url":null,"abstract":"A molecularly imprinted polymer has been prepared using a hexestrol template. The polymer was synthesised using diethylaminoethyl methacrylate (DAEM) as functional monomer and trimethylolpropane trimethacrylate as cross-linking monomer via a photoinitiated addition polymerisation. An equivalent blank polymer was also synthesised in the absence of the template compound. After packing into a stainless steel column (150 × 4.6 mm id), retention and elution of the template and related compounds were evaluated by high-performance liquid chromatography (HPLC). The results showed that the material synthesised in the presence of hexestrol demonstrated a selectivity towards compounds containing the stilbene carbon backbone (diethylstilbestrol, dienestrol, hexestrol).","PeriodicalId":7814,"journal":{"name":"Analytical Communications","volume":"18 1","pages":"105-107"},"PeriodicalIF":0.0000,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/A900197B","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
Abstract
A molecularly imprinted polymer has been prepared using a hexestrol template. The polymer was synthesised using diethylaminoethyl methacrylate (DAEM) as functional monomer and trimethylolpropane trimethacrylate as cross-linking monomer via a photoinitiated addition polymerisation. An equivalent blank polymer was also synthesised in the absence of the template compound. After packing into a stainless steel column (150 × 4.6 mm id), retention and elution of the template and related compounds were evaluated by high-performance liquid chromatography (HPLC). The results showed that the material synthesised in the presence of hexestrol demonstrated a selectivity towards compounds containing the stilbene carbon backbone (diethylstilbestrol, dienestrol, hexestrol).
采用己甾醇模板制备了一种分子印迹聚合物。以甲基丙烯酸二乙胺乙酯(DAEM)为功能单体，三甲基丙烷三甲基丙烯酸三酯为交联单体，通过光引发加成聚合反应合成了该聚合物。在没有模板化合物的情况下，也合成了等效的空白聚合物。在不锈钢柱(150 × 4.6 mm id)中填充后，采用高效液相色谱法(HPLC)评价模板及相关化合物的保留和洗脱。结果表明，在己雌醇存在下合成的材料对含有二苯乙烯碳主链的化合物(二乙基己雌酚、二烯雌醇、己雌醇)具有选择性。
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