{"title":"Synthesis & characterization of iron-carboxylate nanoscale metal organic frameworks for drug delivery","authors":"Vandana Gupta, A. Paul, S. Tyagi","doi":"10.1109/ISPTS.2015.7220125","DOIUrl":null,"url":null,"abstract":"MIL-101-Fe (Materials of Institute Lavoisier) nanoscale-metal organic frameworks (NMOFs) were synthesized by solvothermal method with constant heating at 200°C in silicon oil bath. The as prepared MIL-101-Fe nanoparticles are observed to have particle size in the range of 200-210 nm with multiple shape morphology. Further as prepared MIL-101-Fe are functionalized by incorporating amine group into the framework. Drug loaded NMOF were coated with silica to control the rate of release of drug by avoiding rapid degradation of the NMOF in alkaline pH of PBS buffer. The drug release profile showed that the drug from MIL-101-Fe is released completely in ~32 hrs while for SiO2@Drug@ MIL-101-Fe is extended upto 75 hrs. Silica coated SiO2@Drug@ NH2-MIL-101-Fe particles had adequate stability for drug delivery application.","PeriodicalId":6520,"journal":{"name":"2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)","volume":"17 1","pages":"260-263"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 2nd International Symposium on Physics and Technology of Sensors (ISPTS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ISPTS.2015.7220125","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
MIL-101-Fe (Materials of Institute Lavoisier) nanoscale-metal organic frameworks (NMOFs) were synthesized by solvothermal method with constant heating at 200°C in silicon oil bath. The as prepared MIL-101-Fe nanoparticles are observed to have particle size in the range of 200-210 nm with multiple shape morphology. Further as prepared MIL-101-Fe are functionalized by incorporating amine group into the framework. Drug loaded NMOF were coated with silica to control the rate of release of drug by avoiding rapid degradation of the NMOF in alkaline pH of PBS buffer. The drug release profile showed that the drug from MIL-101-Fe is released completely in ~32 hrs while for SiO2@Drug@ MIL-101-Fe is extended upto 75 hrs. Silica coated SiO2@Drug@ NH2-MIL-101-Fe particles had adequate stability for drug delivery application.
采用溶剂热法制备了MIL-101-Fe (Materials of Institute of Lavoisier)纳米金属有机骨架(NMOFs)。所制备的MIL-101-Fe纳米颗粒粒径在200 ~ 210 nm之间，具有多种形状形态。此外，制备的MIL-101-Fe通过在框架中加入胺基而被功能化。用二氧化硅包被载药的NMOF，通过避免NMOF在碱性PBS缓冲液中快速降解来控制药物的释放速度。药物释放谱显示，MIL-101-Fe中的药物在~32小时内完全释放，而SiO2@Drug@ MIL-101-Fe的药物释放时间延长至75小时。二氧化硅包覆SiO2@Drug@ NH2-MIL-101-Fe颗粒具有足够的药物传递应用稳定性。
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