Ipnmicrospheres for Controlled Drug Delivery: An Overeview

Abstract

Oral modified or controlled dosage forms have always been validated to be a more effective opportunity than conventional or immediate release dosage forms. Controlled or modified drug transport systems provide several benefits of delivering a drug to the body in a specific way to reduce its undesirable side effects and maximize its profit. It also improves the therapeutic efficacy of the drug, decreases toxicity, and with better patient compliance and convenience. In the beyond few decades, microspheres have promised targeted or controlled delivery of drugs in the body which proved to be higher than the conventional drug delivery. It also used to deliver drugs, vaccines, antibiotics, and hormones in a controlled way. Interpenetrating polymer networks have gained a lot of interest in drug delivery systems due to their ease of modification during their synthesis and development state, which evolved novel physicochemical and mechanical properties within the formulation. Interpenetrating polymer network (IPN) systems use novel polymers which are synthesized through the interlacing of two independent polymers in a cross-linked form. The polymers used to formulate an IPN system are independently cross-linked or cross-linked to each other. The present review aims to summarize the IPNmicrospheres systems in terms of their merits, classification, mechanism, method of formulation, evaluation and recent advances in the research field of IPN microspheres.