Meta-Analysis: Relationship of History of Acute Respiratory Infections and Low Birth Weight with Stunting in Toddlers

Kharis Faridan, M. Noor, A. Yasmina, S. Arifin, Harapan Parlindungan Ringoringo
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Abstract

     Basic Health Research (2018) and National Socio-Economic Survey (2019) showed a high incidence of stunting in Indonesia. History of acute respiratory infection (ARI) and low birth weight (LBW) were studied as factors associated with stunting in under-five children. The research’s objective was to analyze the association between the history of ARI and LBW with the incidence of stunting in under-five children. This study was a meta-analysis. Literature searching was conducted in reputed and accredited journals in PubMed and Google Scholar, published between 2016-2020, analytic observational study design, contained OR/PR/RR with 95% confidence interval, written in English or Indonesian, and available in full-text. The meta-analysis was conducted with RevMan 5.4 application. We included 14 studies. Results showed there was a significant association between history of ARI and the incidence of stunting in under-five children, with pooled OR = 2.48 (95%CI = 1.82-3.40, p < 0.00001, I2 = 0%, p for heterogeneity = 0.66). This study showed there was a significant association between LBW and incidence of stunting, with pooled OR = 2.15 (95% CI = 1.58-2.93, p < 0.00001, I2 = 61%, p for heterogeneity = 0.005). The conclusions were there were significant associations between the history of ARI and LBW with the incidence of stunting in under-five children.
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荟萃分析:急性呼吸道感染史与低出生体重与幼儿发育迟缓的关系
基础卫生研究(2018年)和国家社会经济调查(2019年)显示,印度尼西亚发育迟缓的发生率很高。研究了急性呼吸道感染(ARI)史和低出生体重(LBW)作为5岁以下儿童发育迟缓的相关因素。该研究的目的是分析急性呼吸道感染史和低体重与五岁以下儿童发育迟缓发生率之间的关系。这项研究是一项荟萃分析。文献检索在PubMed和Google Scholar的知名和认可期刊中进行,发表于2016-2020年之间,分析性观察性研究设计,包含95%置信区间的OR/PR/RR,以英文或印尼语撰写,并提供全文。meta分析采用RevMan 5.4软件进行。我们纳入了14项研究。结果显示,ARI病史与5岁以下儿童发育迟缓发生率存在显著相关性,合并OR = 2.48 (95%CI = 1.82 ~ 3.40, p < 0.00001, I2 = 0%, p为异质性= 0.66)。本研究显示,低体重与发育迟缓发生率存在显著相关性,合并OR = 2.15 (95% CI = 1.58-2.93, p < 0.00001, I2 = 61%, p为异质性= 0.005)。结论是ARI病史和低体重与5岁以下儿童发育迟缓发生率之间存在显著关联。
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